Krabek Rikke, Bergholt Thomas, Johansen Marianne, Nørgaard Lone Nikoline, Heiring Christian, Dziegiel Morten Hanefeld, Ekelund Charlotte Kvist
Ugeskr Laeger. 2021 Aug 9;183(32).
The incidence of haemolytic disease of the foetus or newborn (HDFN) has decreased considerably in Denmark since the introduction of routine administration of prophylactic anti-D immunoglobulin to RhD-negative pregnant women carrying a RhD-positive foetus. RhD-positive pregnant women are screened for irregular antibodies only in the first trimester of their pregnancy, as their risk of clinically relevant immunisation during pregnancy has been considered very low. This is a case report of severe undetected alloimmunisation causing fatal HDFN after the first trimester in a RhD-positive woman.
自对怀有RhD阳性胎儿的RhD阴性孕妇常规给予预防性抗-D免疫球蛋白以来，丹麦胎儿或新生儿溶血病（HDFN）的发病率已大幅下降。RhD阳性孕妇仅在妊娠早期筛查不规则抗体，因为她们在孕期发生临床相关免疫的风险被认为非常低。本文报告了一例RhD阳性女性在妊娠早期后发生严重未被检测到的同种免疫导致致命性HDFN的病例。
