Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Department of Pathology and Oral Diagnosis, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Oral Dis. 2023 Mar;29(2):796-802. doi: 10.1111/odi.14001. Epub 2021 Aug 20.
To assess the oral shedding and viremia of Epstein-Barr virus (EBV) in HIV-positive patients and their relationship with oral hairy leukoplakia (OHL).
A total of 94 HIV-positive patients were included in the study, in which blood and saliva samples were collected for EBV quantification. Data on gender, age, time of HIV seropositivity, combined antiretroviral therapy (cART), CD4+ T-cell counts, and HIV viral load were collected. OHL diagnosis was based on histopathological examination and EBV in situ hybridization.
The EBV load in the 94 HIV-positive patients was higher in saliva than in blood (2.4 and 1.6, respectively), and there was a positive correlation between EBV oral shedding and viremia (p = 0.001). Twenty (21.27%) patients had OHL and also a higher EBV load in saliva (mean log = 3.11) compared to those who had no OHL (p = 0.045). Presence of OHL was only associated with age (p = 0.030).
In HIV-positive patients, the presence of OHL was associated with EBV oral shedding but not with viremia, regardless of the amount of circulating CD4+ T cells.
评估 HIV 阳性患者的口腔 EBV 脱落和病毒血症及其与口腔毛状白斑（OHL）的关系。
本研究共纳入 94 例 HIV 阳性患者，采集血和唾液样本进行 EBV 定量。收集性别、年龄、HIV 血清阳性时间、联合抗逆转录病毒治疗（cART）、CD4+T 细胞计数和 HIV 病毒载量等数据。OHL 的诊断基于组织病理学检查和 EBV 原位杂交。
94 例 HIV 阳性患者唾液中的 EBV 载量高于血液（分别为 2.4 和 1.6），且 EBV 口腔脱落与病毒血症呈正相关（p=0.001）。20 例（21.27%）患者有 OHL，且唾液中的 EBV 载量更高（平均对数 3.11），与无 OHL 患者相比（p=0.045）。OHL 的存在仅与年龄有关（p=0.030）。
在 HIV 阳性患者中，OHL 的存在与 EBV 口腔脱落有关，而与病毒血症无关，与循环 CD4+T 细胞数量无关。
