Neurosurgery Division, San Luca Hospital, Lucania, Italy.
Neurosurgery Division, Del Mare Hospital, Napoli, Italy.
Surg Technol Int. 2021 Aug 11;39:441-446. doi: 10.52198/21.STI.39.NS149.
To preliminarily assess the effectiveness of a highly viscous antibiotic-loaded hydrogel used as a coating for the prevention of superficial and deep Surgical Site Infections (SSIs) after laminectomy and fusion in instrumented vertebral surgery.
We performed a retrospective cohort analysis on 73 consecutive patients who underwent surgery from June 2018 to December 2019 for degenerative spinal disorders (DSD) or traumatic fractures with segmental instability. Patients received the antibiotic-loaded hydrogel over the implants perioperatively and were observed postoperatively for 12 months.
Postoperative evaluations showed no adverse events in the study population. None of the patients reported significant pain or functional limitation after surgery. Post-surgically, computed tomography scans confirmed the correct positioning of instruments. At 12 months follow-up, no infection was recorded in the overall population.
This retrospective investigation highlights the importance of adopting measures to prevent SSIs in instrumented vertebral surgery. The intraoperative local use of an antibiotic-loaded hydrogel, complementary to systemic antibiotic therapy, appears to minimize the risk of superficial and deep infection.
初步评估一种高粘度抗生素载药水凝胶作为涂层在椎管减压植骨融合术后预防浅表和深部手术部位感染（SSI）的效果。
我们对 2018 年 6 月至 2019 年 12 月因退行性脊柱疾病（DSD）或节段性不稳定的创伤性骨折接受手术的 73 例连续患者进行回顾性队列分析。患者在围手术期接受抗生素载药水凝胶覆盖在植入物上，并在术后 12 个月内进行观察。
术后评估显示研究人群无不良事件。术后，所有患者均未报告明显疼痛或功能受限。术后 CT 扫描证实器械定位正确。在 12 个月的随访中，总体人群中未记录到感染。
这项回顾性研究强调了在器械性脊柱手术中采取措施预防 SSI 的重要性。术中局部应用抗生素载药水凝胶，与全身抗生素治疗相结合，似乎可以最大限度地降低浅表和深部感染的风险。
