羽衣甘蓝对肝脏酶的影响：系统评价和荟萃分析。
The effects of Cynara scolymus L. supplementation on liver enzymes: A systematic review and meta-analysis.
机构信息
Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Food Security Research Center and Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Clin Pract. 2021 Nov;75(11):e14726. doi: 10.1111/ijcp.14726. Epub 2021 Aug 23.
OBJECTIVE
A systematic review and meta-analysis was conducted to summarise studies conducted on the effects of artichoke supplementation on liver enzymes.
METHODS
Suitable studies were detected by searching online databases, including Medline, Embase, Cochrane Library, and Scopus databases, until 05 June 2021. As liver enzymes were reported in different units, standardised mean differences (SMD) were used and data were pooled using a random-effects model. Heterogeneity, publication bias, and sensitivity analysis were also assessed.
RESULTS
Pooled analysis, of eight clinical trials, revealed that artichoke supplementation significantly reduced the concentration of aspartate aminotransferase (AST) (P = .001) and alanine transaminase (ALT) (P = .016), in comparison with placebo. Subgroup analysis suggested that artichoke administration significantly reduces AST and ALT in patients with non-alcoholic fatty liver disease (P = .003 for AST and P < .001 for ALT), and ALT among overweight/obese subjects (P = .025).
CONCLUSIONS
Artichoke supplementation elicited significant reductions in liver enzymes, especially among patients with non-alcoholic fatty liver disease.
目的
系统评价和荟萃分析旨在总结关于朝鲜蓟补充剂对肝酶影响的研究。
方法
通过搜索在线数据库，包括 Medline、Embase、Cochrane 图书馆和 Scopus 数据库，检索截至 2021 年 6 月 5 日的合适研究。由于肝酶以不同单位报告，因此使用标准化均数差（SMD）并使用随机效应模型汇总数据。还评估了异质性、发表偏倚和敏感性分析。
结果
对八项临床试验的汇总分析表明，与安慰剂相比，朝鲜蓟补充剂可显著降低天门冬氨酸氨基转移酶（AST）（P =.001）和丙氨酸氨基转移酶（ALT）（P =.016）的浓度。亚组分析表明，朝鲜蓟给药可显著降低非酒精性脂肪性肝病患者的 AST 和 ALT（AST 为 P =.003，ALT 为 P <.001）以及超重/肥胖受试者的 ALT（P =.025）。
结论
朝鲜蓟补充剂可显著降低肝酶，尤其是在非酒精性脂肪性肝病患者中。
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