Vrentzos Emmanouil, Pavlidis George, Korakas Emmanouil, Kountouri Aikaterini, Pliouta Loukia, Dimitriadis George D, Lambadiari Vaia
4th Department of Internal Medicine, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
2nd Department of Internal Medicine, Research Unit and Diabetes Center, Medical School, Attikon University Hospital, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Nutrients. 2025 May 13;17(10):1657. doi: 10.3390/nu17101657.
MASLD (Metabolic Dysfunction-Associated Steatotic Liver Disease) is a growing global concern. Nutraceuticals offer an appealing approach by targeting key mechanisms, such as oxidative stress, inflammation, lipid metabolism, and insulin resistance. This narrative review examines the role of various nutraceuticals in MASLD treatment, including silymarin, vitamin E, omega-3, curcumin, berberine, and coenzyme Q10. Some of them show promising biochemical and metabolic changes, while others produce conflicting results due to relevant studies' design and endpoints. To bridge the gap between research and reality, we summarize the data, create an interpretation heatmap, and develop a practical supplement guide. Regardless of their potential, nutraceuticals should be viewed as add-ons to lifestyle interventions rather than standalone treatments. Future research should focus on well-designed, long-term studies to prove efficacy, dosing, and combination strategies for personalized MASLD management.
代谢功能障碍相关脂肪性肝病（MASLD）是一个日益受到全球关注的问题。营养保健品通过针对关键机制，如氧化应激、炎症、脂质代谢和胰岛素抵抗，提供了一种有吸引力的方法。这篇叙述性综述探讨了各种营养保健品在MASLD治疗中的作用，包括水飞蓟素、维生素E、ω-3、姜黄素、黄连素和辅酶Q10。其中一些显示出有希望的生化和代谢变化，而另一些由于相关研究的设计和终点而产生了相互矛盾的结果。为了弥合研究与现实之间的差距，我们总结数据、创建解读热图并制定实用的补充指南。无论其潜力如何，营养保健品都应被视为生活方式干预的补充，而非独立的治疗方法。未来的研究应专注于设计良好的长期研究，以证明个性化MASLD管理的疗效、剂量和联合策略。
