针对 COVID-19、糖尿病、性别和年龄对一些实验室参数变化的多变量分析模型。

A Multivariate Analysis Model of Changes in Some Laboratory Parameters in Response to COVID-19, Diabetes, Gender, and Age.

出版信息

Clin Lab. 2021 Aug 1;67(8). doi: 10.7754/Clin.Lab.2021.210106.

DOI:10.7754/Clin.Lab.2021.210106

Abstract

BACKGROUND

The aim of this study was to investigate changes in some laboratory parameters in response to four independent variables (COVID-19, diabetes, gender, and age) using univariate and multivariate analysis.

METHODS

We measured WBC (neutrophil and lymphocytes), RBC and platelet counts, and hemoglobin, lactate dehydrogenase, C-reactive protein, IL-2, IL-4, and vitamin D3 levels in 30 hospitalized patients with severe COVID-19 and in 30 healthy people in terms of COVID-19. The population was divided into groups based on each of the variables of age, gender, COVID-19, and type 2 diabetes. Then they were subjected to univariate and multivariate analysis of logistic regression.

RESULTS

Based on CBC data, leukocytosis (in 70% of COVID-19 patients, 61.1% of diabetic patients, and 70.9 ± 18 years old), neutrophilia (in 73.3% of patients with COVID-19, 61.1% of diabetic patients, and 66 ± 18.6 years old), neutropenia (in 6.7% of patients with COVID-19, 27.8% of diabetic patients, and 33.6 ± 12.7 years old), lymphocytosis (10% of patients with COVID-19, 33.3% of diabetic patients, and 35.4 ± 15.5 years old), and lymphocytopenia (in 76.7% of patients with COVID-19, 66.7% of diabetic patients, and 67.1 ± 18.8 years old) were observed in the population. The elderly and those with COVID-19 had significant abnormal RBC and platelet counts. Increased LDH and CRP levels and abnormal hemoglobin level were related to elderly, COVID-19, and diabetes conditions. Although the levels of IL-2 and -4 were significant in patients with COVID-19 and elderly; however, the changes were not significant in diabetic patients. Changes in serum vitamin D levels were not significant in any of the sub-groups.

CONCLUSIONS

We showed that leukocytosis, neutrophilia, lymphocytopenia, abnormal counts of RBCs and platelets, the elevated levels of LDH and CRP, and abnormal hemoglobin levels in blood are considered as poor prognostic factors for COVID-19.

摘要

背景

本研究旨在通过单变量和多变量分析，研究四项独立变量（COVID-19、糖尿病、性别和年龄）对某些实验室参数的变化。

方法

我们测量了 30 名住院严重 COVID-19 患者和 30 名健康人的白细胞计数（中性粒细胞和淋巴细胞）、红细胞和血小板计数以及血红蛋白、乳酸脱氢酶、C 反应蛋白、IL-2、IL-4 和维生素 D3 水平。根据年龄、性别、COVID-19 和 2 型糖尿病等变量将人群分为几组。然后，他们接受了单变量和多变量逻辑回归分析。

结果

根据 CBC 数据，白细胞增多症（70%的 COVID-19 患者、61.1%的糖尿病患者和 70.9±18 岁）、中性粒细胞增多症（73.3%的 COVID-19 患者、61.1%的糖尿病患者和 66±18.6 岁）、中性粒细胞减少症（6.7%的 COVID-19 患者、27.8%的糖尿病患者和 33.6±12.7 岁）、淋巴细胞增多症（10%的 COVID-19 患者、33.3%的糖尿病患者和 35.4±15.5 岁）和淋巴细胞减少症（76.7%的 COVID-19 患者、66.7%的糖尿病患者和 67.1±18.8 岁）在人群中观察到。老年人和 COVID-19 患者的 RBC 和血小板计数异常显著。LDH 和 CRP 水平升高和血红蛋白水平异常与年龄、COVID-19 和糖尿病有关。尽管 COVID-19 患者和老年人的 IL-2 和-4 水平显著，但糖尿病患者的变化不显著。血清维生素 D 水平的变化在任何亚组中均不显著。