Clin Lab. 2021 Aug 1;67(8). doi: 10.7754/Clin.Lab.2021.201114.
The leading cause of death in patients with chronic kidney disease (CKD) is atherosclerosis (AS). Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a biomarker of atherosclerotic plaque stability. The aim of our study was to analyze the association of Lp-PLA2 with CKD complicated with carotid atherosclerotic stenosis (CAS).
Serum specimens were collected from 77 CKD patients and 39 healthy controls. Laboratory examination results including glucose, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and Lp-PLA2 were measured. Receiver operating characteristic (ROC) was drawn and the area under the curve (AUC) was calculated.
Multivariate logistic regression analysis showed that age, gender, glucose, and Lp-PLA2 were considered as risks for CKD-CAS with odds ratios (OR) of 1.111 (95% CI: 1.055, 1.170), 5.123 (95% CI: 1.482, 17.714), 1.679 (95% CI: 1.123, 2.512), and 1.023 (95% CI: 1.008, 1.037), respectively. The AUC for Lp-PLA2 and glucose was 0.618 (p = 0.014) and 0.592 (p = 0.057), respectively. The best diagnostic value was archived by Lp-PLA2 with the cutoff value of 201.06 ng/mL.
Lp-PLA2 is a potential prognostic and diagnostic biomarker for CKD-CAS.
慢性肾脏病（CKD）患者的主要死亡原因是动脉粥样硬化（AS）。脂蛋白相关磷脂酶 A2（Lp-PLA2）是动脉粥样斑块稳定性的生物标志物。本研究旨在分析 Lp-PLA2 与 CKD 合并颈动脉粥样硬化狭窄（CAS）的关系。
收集 77 例 CKD 患者和 39 例健康对照者的血清标本。检测血糖、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和 Lp-PLA2 等实验室检查结果。绘制受试者工作特征（ROC）曲线并计算曲线下面积（AUC）。
多因素 logistic 回归分析显示，年龄、性别、血糖和 Lp-PLA2 是 CKD-CAS 的危险因素，比值比（OR）分别为 1.111（95%CI：1.055，1.170）、5.123（95%CI：1.482，17.714）、1.679（95%CI：1.123，2.512）和 1.023（95%CI：1.008，1.037）。Lp-PLA2 和血糖的 AUC 分别为 0.618（p=0.014）和 0.592（p=0.057）。Lp-PLA2 的最佳截断值为 201.06ng/mL，诊断价值最高。
Lp-PLA2 是 CKD-CAS 的潜在预后和诊断生物标志物。
