Amity Institute of Applied Sciences, Amity University Uttar Pradesh, NOIDA, India.
Amity Institute of Click Chemistry Research and Studies, Amity University Uttar Pradesh, NOIDA, India.
Int J Biol Macromol. 2021 Oct 1;188:542-567. doi: 10.1016/j.ijbiomac.2021.08.036. Epub 2021 Aug 10.
Over the past few years, amino acids (AA) have emerged as promising biomaterials for the synthesis of functional polymers. Owing to the diversity of functional groups in amino acids, various polymerization methods may be used to make a wide range of well-defined functional amino-acid/peptide-based optically active polymers with varying polymer lengths, compositions, and designs. When incorporated with chirality and self-assembly, they offer a wide range of applications and are particularly appealing in the field of drug delivery, tissue engineering, and biosensing. There are several classes of these polymers that include polyamides (PA), polyesters (PE), poly(ester-amide)s (PEA)s, polyurethanes (PU)s, poly(depsipeptide)s (PDP)s, etc. They offer the ability to control functionality, conjugation, crosslinking, stimuli responsiveness, and tuneable mechanical/thermal properties. In this review, we present the recent advancements in the synthesis strategies for obtaining these amino acid-derived bio-macromolecules, their self-assembly properties, and the wealth of prevalent applications.
在过去的几年中，氨基酸 (AA) 已成为合成功能性聚合物的有前途的生物材料。由于氨基酸中官能团的多样性，可以使用各种聚合方法来制造具有不同聚合物长度、组成和设计的各种定义明确的基于功能氨基酸/肽的手性聚合物。当与手性和自组装结合使用时，它们提供了广泛的应用，在手性药物输送、组织工程和生物传感领域特别有吸引力。这些聚合物有几类，包括聚酰胺 (PA)、聚酯 (PE)、聚 (酯酰胺) (PEA)、聚氨基甲酸酯 (PU)、聚 (去酰肽) (PDP) 等。它们提供了控制功能、缀合、交联、刺激响应和可调机械/热性能的能力。在这篇综述中，我们介绍了获得这些氨基酸衍生生物大分子的合成策略的最新进展、它们的自组装特性以及丰富的流行应用。
