Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea.
Exp Gerontol. 2021 Oct 15;154:111513. doi: 10.1016/j.exger.2021.111513. Epub 2021 Aug 10.
The limited available literature suggests that sleep problems are linked to an increased risk of mild cognitive impairment (MCI). However, this association has been little studied to date in low-income settings.
To investigate the association between sleep problems and MCI in a large sample of adults from six low-and middle-income countries (LMICs).
Cross-sectional.
Study on Global Ageing and Adult Health (SAGE).
32,715 individuals aged ≥50 years with preservation in functional abilities [age range 50-114 years; 51.7% females].
MCI was defined using the National Institute on Aging-Alzheimer's Association criteria. Sleep problems were assessed by the question "Overall in the last 30 days, how much of a problem did you have with sleeping, such as falling asleep, waking up frequently during the night or waking up too early in the morning?" and categorized as "None", "Mild", "Moderate", "Severe/Extreme". Multivariable logistic regression analysis and meta-analysis were conducted.
Compared to no sleep problems, mild, moderate, and severe/extreme sleep problems were associated with significant 1.40, 1.83, and 2.69 times higher odds for MCI with similar associations being observed between age groups and sex. Severe/extreme sleep problems were positively associated with MCI (i.e., OR > 1) in the six countries studied with the overall estimate being OR = 1.80 (95% CI = 1.50-2.16), and a low level of between-country heterogeneity was observed (I = 28.2%).
Sleep problems were associated with higher odds for MCI. Interventions to improve sleep quality among middle-aged and older adults in LMICs may be an effective strategy in reducing risk of MCI and dementia.
有限的可用文献表明，睡眠问题与轻度认知障碍（MCI）的风险增加有关。然而，迄今为止，在低收入环境中，这一关联研究甚少。
在来自六个中低收入国家（LMIC）的大量成年人样本中，研究睡眠问题与 MCI 之间的关联。
横断面研究。
全球老龄化与成人健康研究（SAGE）。
32715 名年龄在 50 岁及以上、功能能力保持完好的个体（年龄范围 50-114 岁；51.7%为女性）。
采用美国国家老龄化研究所-阿尔茨海默病协会的标准来定义 MCI。通过问题“在过去 30 天内，您在睡眠方面有多大的问题，例如入睡困难、夜间频繁醒来或清晨醒来过早？”来评估睡眠问题，并将其归类为“无”、“轻度”、“中度”、“重度/极度”。采用多变量逻辑回归分析和荟萃分析进行分析。
与无睡眠问题相比，轻度、中度和重度/极度睡眠问题与 MCI 的几率显著增加 1.40、1.83 和 2.69 倍，且在各年龄组和性别之间观察到类似的关联。在研究的六个国家中，严重/极度睡眠问题与 MCI 呈正相关（即 OR>1），总体估计值为 OR=1.80（95%CI=1.50-2.16），且观察到国家间异质性水平较低（I=28.2%）。
睡眠问题与 MCI 的几率增加有关。在中低收入国家改善中年和老年人的睡眠质量可能是降低 MCI 和痴呆风险的有效策略。
