Medical Biomaterial Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran.
Department of Toxicology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
J Trace Elem Med Biol. 2021 Dec;68:126836. doi: 10.1016/j.jtemb.2021.126836. Epub 2021 Aug 5.
Arsenic is found in soil, food, water and earth crust. Arsenic exposure is associated with chronic diseases such as cancer, cardiovascular disease as well as diabetes. One of complex effects of arsenic is on weight gain or loss. Involvement of arsenic in both weight loss and gain signaling pathways has previously been reported; however, too little attention has been paid to its weight reducing effect. Animal studies exhibited a role of arsenic in weight loss. In this regard, arsenic interference with endocrine system, leptin and adiponectin hormones as well as thermogenesis is more evidence. Apparently, arsenic-induced weight lossis generally meditated by its interaction with thermogenesis. In this review we have discussed the irregularities in metabolic pathways induced by arsenic that can lead to weight loss.
砷存在于土壤、食物、水和地壳中。砷暴露与癌症、心血管疾病和糖尿病等慢性疾病有关。砷的复杂影响之一是体重增加或减少。以前曾有报道称砷参与了体重减轻和增加的信号通路；然而，人们对其减肥效果关注甚少。动物研究表明砷在减肥中有一定作用。在这方面，砷对内分泌系统、瘦素和脂联素激素以及产热的干扰提供了更多证据。显然，砷诱导的体重减轻通常是通过其与产热的相互作用介导的。在这篇综述中，我们讨论了砷引起的代谢途径异常，这些异常可能导致体重减轻。
