Department of Pediatrics, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Department of Pediatric Cardiology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Cardiol Young. 2022 Jun;32(6):888-895. doi: 10.1017/S1047951121003206. Epub 2021 Aug 13.
Children with a family history of hypertension have higher blood pressure and hypertensive pathophysiological changes begin before clinical findings. Here, the presence of arterial stiffness was investigated using central blood pressure measurement and pulse wave analysis in normotensive children with at least one parent with essential hypertension. Twenty-four-hour ambulatory pulse wave analysis monitoring was performed by oscillometric method in a study group of 112 normotensive children of hypertensive parents aged between 7 and 18 comparing with a control group of 101 age- and gender-matched normotensive children of normotensive parents. Pulse wave velocity, central systolic and diastolic blood pressure, systolic, diastolic and mean arterial blood pressure values were higher in the study group than the control group (p < 0.001, p = 0.002, p = 0.008, p = 0.001, p = 0.005, p = 0.001, p = 0.001, respectively). In all age groups (7-10, 11-14, and 15-18 years), pulse wave velocity was higher in the study group than the control group (p < 0.001). Pulse wave velocity was higher in children whose both parents are hypertensive compared to the children whose only mothers are hypertensive (p = 0.011). Pulse wave velocity values were positively correlated with age, weight, height, and body mass index (p < 0.05). Higher pulse wave velocity, central systolic and diastolic blood pressure values detected in the study group can be considered as early signs of hypertensive vascular changes. Pulse wave analysis can be a reliable, non-invasive, and reproducible method that can allow taking necessary precautions regarding lifestyle to prevent disease and target organ damage by detecting early hypertensive changes in genetically risky children.
患有高血压家族史的儿童血压较高，高血压病理生理变化在临床发现之前就已经开始。在这里，通过对至少有一位原发性高血压父母的血压正常儿童进行中心血压测量和脉搏波分析，研究了动脉僵硬度的存在。通过振荡法对 112 名血压正常的高血压父母的血压正常儿童和 101 名年龄和性别匹配的血压正常父母的血压正常儿童进行了 24 小时动态脉搏波分析监测。与对照组相比，研究组的脉搏波速度、中心收缩压和舒张压、收缩压、舒张压和平均动脉血压值均较高（p<0.001，p=0.002，p=0.008，p=0.001，p=0.005，p=0.001，p=0.001）。在所有年龄组（7-10 岁、11-14 岁和 15-18 岁）中，研究组的脉搏波速度均高于对照组（p<0.001）。与只有母亲患有高血压的儿童相比，父母双方均患有高血压的儿童的脉搏波速度更高（p=0.011）。脉搏波速度值与年龄、体重、身高和体重指数呈正相关（p<0.05）。研究组中较高的脉搏波速度、中心收缩压和舒张压值可被视为高血压血管变化的早期迹象。脉搏波分析可以是一种可靠、非侵入性和可重复的方法，可以通过检测遗传风险儿童的早期高血压变化，采取必要的生活方式预防措施，预防疾病和靶器官损伤。
