Li Chia-Lin, Chiu Yu-Chan, Shyu Yea-Ing L, Stanaway Fiona F, Chang Hsing-Yi, Bai Yuh-Bin
Department of Health Care Management, College of Management, Chang Gung University, Taoyuan, Taiwan.
Department of Bio-Industry Communication and Development, National Taiwan University, Taipei, Taiwan.
Arch Gerontol Geriatr. 2021 Nov-Dec;97:104500. doi: 10.1016/j.archger.2021.104500. Epub 2021 Aug 6.
The main aim of this study was to examine how physical activity in combination with physical frailty and cognitive impairment affects risk of mortality in older adults.
A national sample of community-dwelling Taiwanese aged 65 years or older (n=2678) was followed for 5 years.
Frailty was determined based on the Fatigue, Resistance, Ambulation, Illness, and Loss of weight (FRAIL) scale. The Mini-Mental State Examination was used to assess cognitive impairment. Information on self-reported physical activity was collected at baseline. The study cohort was followed until the date of death or the end of the study period (31 December 2018). Deaths were confirmed by the computerized data files of the National Register of Deaths.
A total of 417 deaths were recorded after 12415.2 person-years of follow-up. After adjustment for other factors, compared with active participants who were physically robust with normal cognition, inactive participants who were with either frail/pre-frail or cognitively impaired had hazard ratios for mortality of 2.65 (95% CI=[1.88-3.74]) and 3.09 (95% CI=[2.08-4.59]), respectively. Inactive participants with coexisting frailty/pre-frailty and cognitive impairment had the highest hazard ratio for mortality of 3.85 (95% CI=[2.73-5.45]). Being active was associated with a mortality reduction of 31%, 38%, and 42% in physically robust participants with normal cognition, those who were frail/pre-frail only, and those with cognitive impairment only, respectively.
Having a physically active life style has beneficial effects on survival in older persons with either frailty/pre-frailty or cognitive impairment.
本研究的主要目的是探讨身体活动与身体虚弱及认知障碍相结合如何影响老年人的死亡风险。
对2678名年龄在65岁及以上的台湾社区居民进行了为期5年的全国性抽样随访。
根据疲劳、抵抗力、步行能力、疾病和体重减轻（FRAIL）量表确定虚弱程度。使用简易精神状态检查表评估认知障碍。在基线时收集自我报告的身体活动信息。对研究队列进行随访，直至死亡日期或研究期结束（2018年12月31日）。通过国家死亡登记处的计算机数据文件确认死亡情况。
在12415.2人年的随访后，共记录了417例死亡。在对其他因素进行调整后，与身体强壮且认知正常的活跃参与者相比，身体虚弱/脆弱或认知障碍的不活跃参与者的死亡风险比分别为2.65（95%置信区间=[1.88 - 3.74]）和3.09（95%置信区间=[2.08 - 4.59]）。同时存在虚弱/脆弱和认知障碍的不活跃参与者的死亡风险比最高，为3.85（95%置信区间=[2.73 - 5.45]）。身体强壮且认知正常的参与者、仅身体虚弱/脆弱的参与者以及仅认知障碍的参与者中，活跃状态分别与死亡率降低31%、38%和42%相关。
拥有积极的生活方式对身体虚弱/脆弱或认知障碍的老年人的生存具有有益影响。
