Kim Kyoung Lae, Joo Kwangsic, Park Sang Jun, Park Kyu Hyung, Woo Se Joon
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Ophthalmology, Gangwon National University College of Medicine, Gangwon National University Hospital, Chuncheon, Korea.
Acta Ophthalmol. 2022 May;100(3):e710-e718. doi: 10.1111/aos.14960. Epub 2021 Aug 12.
To investigate the ophthalmic risk factors related to neovascular change and the subtype-wise incidence of progression from intermediate to neovascular age-related macular degeneration (AMD).
In this retrospective cohort study, 632 eyes with intermediate AMD from 418 patients (older than 50 years) were enrolled. The systemic factors and ophthalmic factors were statistically analysed with respect to neovascular change.
The 5-year cumulative incidence of progression to neovascular AMD (nAMD) from intermediate AMD was 17.8% and 17.0% in eyes with soft drusen and pachydrusen (p = 0.316). Older age (p = 0.025), preexisting nAMD in the fellow eye (p < 0.001), and reticular pseudodrusen (RPD; p = 0.007) were associated with the risk of progression to nAMD. In reference to soft drusen, pachydrusen was associated with progression to polypoidal choroidal vasculopathy (PCV; p < 0.001) and not to typical nAMD (p = 0.064).
The ophthalmic risk factors related to the progression of nAMD from intermediate AMD were found to be preexisting nAMD in the fellow eye and RPD. Pachydrusen showed a similar incidence of neovascular change with soft drusen, and was associated with the progression to PCV but not to typical nAMD.
研究与新生血管改变相关的眼科危险因素，以及从中间型年龄相关性黄斑变性（AMD）进展为新生血管性AMD的各亚型发病率。
在这项回顾性队列研究中，纳入了418例（年龄大于50岁）患有中间型AMD的632只眼。对全身因素和眼科因素与新生血管改变进行了统计学分析。
中间型AMD进展为新生血管性AMD（nAMD）的5年累积发病率在存在软性玻璃膜疣和厚壁玻璃膜疣的眼中分别为17.8%和17.0%（p = 0.316）。年龄较大（p = 0.025）、对侧眼已存在nAMD（p < 0.001）和网状假性玻璃膜疣（RPD；p = 0.007）与进展为nAMD的风险相关。与软性玻璃膜疣相比，厚壁玻璃膜疣与息肉样脉络膜血管病变（PCV）进展相关（p < 0.001），而与典型nAMD进展无关（p = 0.064）。
发现与中间型AMD进展为nAMD相关的眼科危险因素为对侧眼已存在nAMD和RPD。厚壁玻璃膜疣与软性玻璃膜疣的新生血管改变发生率相似，且与进展为PCV相关，但与典型nAMD进展无关。
