18F-PSMA-1007 在骨 Paget 病中的摄取：一种“钢铁侠”征象。

18F-PSMA-1007 Uptake in Paget Disease of the Bone: An "Iron Man" Sign.

机构信息

From the Department of Nuclear Medicine, Jaber Al-Ahmad Molecular Imaging Center.

出版信息

Clin Nucl Med. 2022 Mar 1;47(3):249-250. doi: 10.1097/RLU.0000000000003867.

Abstract

18F-PSMA is a promising tracer for both staging and detection of biochemical recurrence in prostate cancer. PSMA is also expressed in the benign pathological conditions. We report a case of 81-year-old man with a known case of prostate cancer who underwent 18F-PSMA for restaging. 18F-PSMA PET/CT shows intense tracer uptake in the frontal bone appearing like an "Iron Man" sign. Corresponding noncontrast CT images, pagetoid changes with thickened cortex, mixed lytic/sclerotic mottled pattern. It is important to recognize 18F-PSMA expression in the benign nonprostatic pathologies to avoid false interpretation.

摘要

18F-PSMA 是一种很有前途的示踪剂，可用于前列腺癌的分期和生化复发的检测。PSMA 也在良性病理情况下表达。我们报告了一例 81 岁男性前列腺癌患者，该患者进行了 18F-PSMA 再分期。18F-PSMA PET/CT 显示额骨有强烈的示踪剂摄取，呈“钢铁侠”征。相应的非对比 CT 图像表现为 paget 样改变，皮质增厚，混合溶骨性/硬化性斑驳样改变。重要的是要识别良性非前列腺病变中的 18F-PSMA 表达，以避免错误解读。