Deshpande Abhinav Prakash, Baburaj Mala Dixit, Tambe Lashika Vasant, Prasad Upendra
Department of Periodontics, Nair Hospital Dental College, Mumbai, Maharashtra, India.
J Indian Soc Periodontol. 2021 Jul-Aug;25(4):313-319. doi: 10.4103/jisp.jisp_440_20. Epub 2021 Jul 1.
The study aims to evaluate the effect of adding extracellular matrix (ECM) component - natural collagen to nanocrystalline hydroxyapatite (nHA) bone graft in the treatment of intrabony defect in chronic periodontitis patients.
Forty chronic periodontitis patients having at least one intrabony defect were treated surgically by open flap debridement and the defect grafted (Group A: 20 sites grafted with nHA with natural collagen and Group B: 20 sites grafted with nHA). Plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and radiographic defect depth (RDD) were evaluated.
The mean PPD reduced from 7.6 ± 0.88 at baseline to 4.45 ± 0.69 and 2.60 ± 0.6 at 3 and 6 months, respectively, in Group A. In Group B, the mean PPD reduced from 7.5 ± 0.89 at baseline to 4.95 ± 0.60 and 2.65 ± 0.59 at 3 and 6 months, respectively. The mean CAL reduced from 7.75 ± 0.85 at baseline to 5.05 ± 0.76 and 3.6 ± 0.68 at 3 and 6 months, respectively, in Group A. In Group B, the mean CAL reduced from 7.70 ± 0.86 at baseline to 5.8 ± 0.7 and 3.75 ± 0.64 at 3 and 6 months, respectively. The mean RDD reduced from 8.13 ± 0.78 and 8.12 ± 0.83 at baseline to 4.27 ± 0.66 and 3.94 ± 0.5 after 6 months in Groups A and B, respectively. After 3 months, a statistically significant reduction in mean PPD and CAL values was noted in Group A while the results were comparable after 6 months.
The effectiveness of nHA composite during initial healing phase (3 months) can be attributed to the presence of ECM-collagen in bone graft matrix.
本研究旨在评估在纳米晶羟基磷灰石（nHA）骨移植材料中添加细胞外基质（ECM）成分——天然胶原蛋白，对慢性牙周炎患者骨内缺损的治疗效果。
40例患有至少一处骨内缺损的慢性牙周炎患者接受了手术治疗，采用开放瓣清创术并对缺损部位进行植骨（A组：20个部位植入含天然胶原蛋白的nHA；B组：20个部位植入nHA）。评估菌斑指数、牙龈指数、探诊深度（PPD）、临床附着水平（CAL）和影像学缺损深度（RDD）。
A组平均PPD从基线时的7.6±0.88分别降至3个月时的4.45±0.69和6个月时的2.60±0.6。B组平均PPD从基线时的7.5±0.89分别降至3个月时的4.95±0.60和6个月时的2.65±0.59。A组平均CAL从基线时的7.75±0.85分别降至3个月时的5.05±0.76和6个月时的3.6±0.68。B组平均CAL从基线时的7.70±0.86分别降至3个月时的5.8±0.7和6个月时的3.75±0.64。A组和B组平均RDD从基线时的8.13±0.78和8.12±0.83分别降至6个月后的4.27±0.66和3.94±0.5。3个月后，A组平均PPD和CAL值有统计学意义的降低，而6个月后结果相当。
nHA复合材料在初始愈合阶段（3个月）的有效性可归因于骨移植基质中存在ECM - 胶原蛋白。
