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G骨(羟基磷灰石)和G-移植物(含胶原蛋白的羟基磷灰石)作为下颌第三磨牙拔牙窝骨移植材料的比较评价

Comparative Evalution of G bone (Hydroxyapatite) and G-Graft (Hydroxyapatite with Collagen) as Bone Graft Material in Mandibular III Molar Extraction Socket.

作者信息

Panday Vijayendra, Upadhyaya Vivekananda, Berwal Vikas, Jain Kapil, Sah Nupur, Sarathi Partha, Swami Pushp Chander

机构信息

Associate Professor (Periodontics), Department of Dentistry, SMIMS Gangtok E.Sikkim, India .

Professor and Head, Department of Periodontology, Hazaribag College of Dental Sciences , Hazaribag, Jharkhand, India .

出版信息

J Clin Diagn Res. 2015 Mar;9(3):ZC48-52. doi: 10.7860/JCDR/2015/12140.5713. Epub 2015 Mar 1.

Abstract

BACKGROUND

Bone grafting is a dynamic phenomenon. It is a surgical procedure that replaces missing bone with material either from patient's own body, or, an artificial, synthetic or natural substitute. A successful bone graft when applied, heals, becomes incorporated, re-vascularises and eventually assumes the form desired.

AIMS AND OBJECTIVE

The main purpose of this present study was to radiologically assess and compare the regenerative potential of hydroxyapatite with Collagen (G-Graft) and hydroxyapatite (G-Bone) and to evaluate the clinical usefulness of these materials to enhance bone healing in third molar extraction sites through bone formation.

MATERIALS AND METHODS

The study was carried out in the Department of Oral & Maxillofacilal Surgery, patients were divided into three groups. The rationale for assigning the patients to the groups was strictly random: Group I - G-Graft (Hydroxyapatite with Collagen) was used as Bone graft material, Group II - Bone graft material used was G-Bone (Hydroxyapatite), Group III-control group (no grafts was used). Orthopentomogram(OPG) images were taken intra-operatively, just after extraction in the Group III (control), after extraction but before graft placement in Group I & II (study groups) and post-operatively at the end of first month and third month. Bone density of the post-extraction sockets was measured at four random areas through 'densitometric analysis' software in the OPG program (Kodak 8000C Digital Panoramic System, Eastman Kodak Company) and an average value was recorded at each review.

RESULTS

The percentage increase in bone density between 1(st) month & 3(rd) month was 7.55± 12.43 in Group I (G Graft), 4.41± 5.4859 in Group II (G Bone), while that Group III (control) was found to be -0.82 ± 3.96. The bone density increase was found to be statistically highly significant (p<0.01)) between all groups.

CONCLUSION

The present study concluded that G-Graft has a definite regenerative potential and is better than G-bone and can be used in bony defects to enhance the bone healing without provoking any significant inflammatory process. The study also indicates that defects treated with G-Graft attain more density initially and that G-Graft enhances bone healing in early stage.

摘要

背景

骨移植是一个动态过程。它是一种外科手术,用来自患者自身身体的材料或人工、合成或天然替代品来替代缺失的骨头。成功应用的骨移植会愈合、融入、重新血管化并最终呈现出所需的形态。

目的

本研究的主要目的是通过放射学评估和比较羟基磷灰石与胶原蛋白(G - 移植材料)和羟基磷灰石(G - 骨)的再生潜力,并评估这些材料通过骨形成来促进第三磨牙拔牙位点骨愈合的临床实用性。

材料与方法

该研究在口腔颌面外科进行,患者被分为三组。将患者分配到各组的依据是严格随机的:第一组 - 使用G - 移植材料(含胶原蛋白的羟基磷灰石)作为骨移植材料,第二组 - 使用的骨移植材料是G - 骨(羟基磷灰石),第三组 - 对照组(未使用移植材料)。在第三组(对照组)拔牙后即刻、第一组和第二组(研究组)拔牙后但在植入移植材料前术中拍摄口腔全景X线片(OPG),并在术后第一个月末和第三个月末拍摄。通过OPG程序(柯达8000C数字全景系统,伊士曼柯达公司)中的“密度分析”软件在四个随机区域测量拔牙窝的骨密度,并在每次复查时记录平均值。

结果

第一组(G - 移植材料组)在第1个月至第3个月期间骨密度增加的百分比为7.55±12.43,第二组(G - 骨组)为4.41±5.4859,而第三组(对照组)为 - 0.82±3.96。发现所有组之间骨密度增加具有高度统计学显著性(p<0.01)。

结论

本研究得出结论,G - 移植材料具有一定的再生潜力,优于G - 骨,可用于骨缺损以促进骨愈合而不会引发任何明显的炎症过程。该研究还表明,用G - 移植材料治疗的缺损最初获得的密度更高,并且G - 移植材料在早期促进骨愈合。

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