小檗碱在代谢应激下通过调节自噬重塑胰岛局部肾素-血管紧张素系统的平衡。
Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets.
机构信息
Department of Endocrinology, Taihe Hospital, Hubei University of Medical, Shiyan, 442000 Hubei, China.
Department of Endocrinology, Bishan Hospital of Chongqing, Bishan, Chongqing 402760, China.
出版信息
J Renin Angiotensin Aldosterone Syst. 2021 Aug 3;2021:9928986. doi: 10.1155/2021/9928986. eCollection 2021.
RESULTS
Prolonged exposure to palmitate increased the expression of ACE and AngII type 1 receptor (ATR1) and decreased the ACE2 expression, which was partly offset by berberine. In ob/ob mice, berberine increased in tolerance to glucose, improved abnormal -cell and -cell distributions, upregulated ACE2 expression, and decreased autophagosomes and the expression of LC3 and SQSTM1/p62. Autophagosomes and expression of LC3 and SQSTM1/p62 were increased in ACE2KO mice.
CONCLUSIONS
We demonstrated that berberine may improve the pancreatic islet function by regulating local RAS-mediated autophagy under metabolic stress.
结果
棕榈酸处理延长可增加 ACE 和血管紧张素 II 型 1 型受体（ATR1）的表达，降低 ACE2 的表达，而小檗碱可部分抵消这种作用。在 ob/ob 小鼠中，小檗碱增加了对葡萄糖的耐受性，改善了异常的β细胞和α细胞分布，上调了 ACE2 的表达，减少了自噬体和 LC3 和 SQSTM1/p62 的表达。ACE2KO 小鼠的自噬体和 LC3 和 SQSTM1/p62 的表达增加。
结论
我们表明，小檗碱可通过调节代谢应激下局部 RAS 介导的自噬来改善胰岛功能。
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