Bohr H, Heerfordt J
Clin Orthop Relat Res. 1977 Nov-Dec(129):209-12. doi: 10.1097/00003086-197711000-00027.
The necrotic femoral head in a patient with a transplanted kidney was examined autoradiographically (with fluorine--18 and Technitium--99 m--Polyphosphate) and histologically (i.e. with long interval Tetracycline labellings). A well circumscribed area of necrotic bone was demonstrated in the weight bearing part of the caput giving evidence of a solitary infarction. The demarcation zone showed revascularization, and appositional bone formation accounted for the increased density. Foci of necrotic bone were observed further away from the necrotic area indicating an originally more extensive vascular insufficiency. In the subchondral bone a fissure had arisen probably due to rarefaction of bone during the process of revascularization. It is suggested that the vascular insufficiency was a result of a reduced resistance of the bone tissue altered by steroid therapy.
对一名肾移植患者的坏死股骨头进行了放射自显影检查（使用氟 - 18和锝 - 99m - 多聚磷酸盐）和组织学检查（即使用长时间间隔四环素标记）。在股骨头的负重部分显示出一个界限清楚的坏死骨区域，证明为孤立性梗死。分界区显示有血管再生，骨的贴附性形成导致密度增加。在距坏死区较远的地方观察到坏死骨灶，表明最初存在更广泛的血管供血不足。在软骨下骨出现了一条裂缝，可能是由于血管再生过程中骨的稀疏所致。提示血管供血不足是类固醇治疗改变了骨组织抵抗力降低的结果。
