• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Deciphering the Electrophysiological Mechanisms for Ibrutinib-Induced Ventricular Arrhythmias.

作者信息

Kudinov Alex, Darbar Dawood

机构信息

Division of Cardiology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA.

Department of Medicine, Jesse Brown Veterans Affairs Medical Center, University of Illinois at Chicago, Chicago, Illinois, USA.

出版信息

JACC CardioOncol. 2020 Nov 17;2(4):630-631. doi: 10.1016/j.jaccao.2020.10.001. eCollection 2020 Nov.

DOI:10.1016/j.jaccao.2020.10.001
PMID:34396274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8352279/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cde/8352279/fb8bb15dab5b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cde/8352279/fb8bb15dab5b/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8cde/8352279/fb8bb15dab5b/fx1.jpg

相似文献

1
Deciphering the Electrophysiological Mechanisms for Ibrutinib-Induced Ventricular Arrhythmias.解读依鲁替尼诱发室性心律失常的电生理机制
JACC CardioOncol. 2020 Nov 17;2(4):630-631. doi: 10.1016/j.jaccao.2020.10.001. eCollection 2020 Nov.
2
Comparative arrhythmia patterns among patients on tyrosine kinase inhibitors.酪氨酸激酶抑制剂治疗患者的心律失常模式比较。
J Interv Card Electrophysiol. 2024 Jan;67(1):111-118. doi: 10.1007/s10840-023-01575-z. Epub 2023 May 31.
3
Arrhythmia Patterns in Patients on Ibrutinib.接受依鲁替尼治疗患者的心律失常模式
Front Cardiovasc Med. 2022 Jan 3;8:792310. doi: 10.3389/fcvm.2021.792310. eCollection 2021.
4
Acute Effects of Ibrutinib on Ventricular Arrhythmia in Spontaneously Hypertensive Rats.依鲁替尼对自发性高血压大鼠室性心律失常的急性影响。
JACC CardioOncol. 2020 Nov 17;2(4):614-629. doi: 10.1016/j.jaccao.2020.08.012. eCollection 2020 Nov.
5
Ibrutinib and Bruton's Tyrosine Kinase Inhibitors in Chronic Lymphocytic Leukemia: Focus on Atrial Fibrillation and Ventricular Tachyarrhythmias/Sudden Cardiac Death.伊布替尼和布鲁顿酪氨酸激酶抑制剂在慢性淋巴细胞白血病中的应用：关注心房颤动和室性心律失常/心源性猝死。
Chemotherapy. 2023;68(2):61-72. doi: 10.1159/000528019. Epub 2022 Nov 10.
6
Cardiovascular Toxicities Associated With Ibrutinib.伊布替尼相关心血管毒性。
J Am Coll Cardiol. 2019 Oct 1;74(13):1667-1678. doi: 10.1016/j.jacc.2019.07.056.
7
Electrocardiographic Changes Associated With Ibrutinib Exposure.伊布替尼暴露相关的心电图改变。
Cancer Control. 2020 Jan-Dec;27(1):1073274820931808. doi: 10.1177/1073274820931808.
8
Cardiovascular Magnetic Resonance Imaging in Patients With Ibrutinib-Associated Cardiotoxicity.伊布替尼相关性心脏毒性患者的心血管磁共振成像。
JAMA Oncol. 2023 Apr 1;9(4):552-555. doi: 10.1001/jamaoncol.2022.6869.
9
Increased Susceptibility for Atrial and Ventricular Cardiac Arrhythmias in Mice Treated With a Single High Dose of Ibrutinib.单次大剂量伊布替尼治疗可增加小鼠心房和心室心律失常的易感性。
Can J Cardiol. 2018 Mar;34(3):337-341. doi: 10.1016/j.cjca.2017.12.001. Epub 2017 Dec 7.
10
Electrophysiology in a district general hospital.地区综合医院的电生理学
Br Heart J. 1995 Jan;73(1):76-81. doi: 10.1136/hrt.73.1.76.

引用本文的文献

1
Cardiotoxicity of small-molecule kinase inhibitors in cancer therapy.小分子激酶抑制剂在癌症治疗中的心脏毒性
Exp Hematol Oncol. 2025 May 9;14(1):68. doi: 10.1186/s40164-025-00660-5.

本文引用的文献

1
Acute Effects of Ibrutinib on Ventricular Arrhythmia in Spontaneously Hypertensive Rats.依鲁替尼对自发性高血压大鼠室性心律失常的急性影响。
JACC CardioOncol. 2020 Nov 17;2(4):614-629. doi: 10.1016/j.jaccao.2020.08.012. eCollection 2020 Nov.
2
Bruton's tyrosine kinase is at the crossroads of metabolic adaptation in primary malignant human lymphocytes.布鲁顿酪氨酸激酶在原发性恶性人淋巴细胞代谢适应的交汇点。
Sci Rep. 2019 Jul 30;9(1):11069. doi: 10.1038/s41598-019-47305-2.
3
Ibrutinib promotes atrial fibrillation by inducing structural remodeling and calcium dysregulation in the atrium.
伊布替尼通过诱导心房结构重塑和钙稳态失调促进心房颤动。
Heart Rhythm. 2019 Sep;16(9):1374-1382. doi: 10.1016/j.hrthm.2019.04.008. Epub 2019 Apr 5.
4
The risk of atrial fibrillation with ibrutinib use: a systematic review and meta-analysis.使用依鲁替尼引发心房颤动的风险：一项系统评价与荟萃分析。
Blood. 2016 Jul 7;128(1):138-40. doi: 10.1182/blood-2016-05-712828. Epub 2016 May 31.
5
Ibrutinib increases the risk of atrial fibrillation, potentially through inhibition of cardiac PI3K-Akt signaling.依鲁替尼增加心房颤动风险，可能是通过抑制心脏PI3K-Akt信号传导实现的。
Blood. 2014 Dec 11;124(25):3829-30. doi: 10.1182/blood-2014-10-604272.
6
Ibrutinib versus ofatumumab in previously treated chronic lymphoid leukemia.伊布替尼与奥法妥木单抗治疗既往治疗的慢性淋巴细胞白血病。
N Engl J Med. 2014 Jul 17;371(3):213-23. doi: 10.1056/NEJMoa1400376. Epub 2014 May 31.
7
Resveratrol attenuates the Na(+)-dependent intracellular Ca(2+) overload by inhibiting H(2)O(2)-induced increase in late sodium current in ventricular myocytes.白藜芦醇通过抑制 H₂O₂诱导的晚期钠电流增加来减轻 Na(+)-依赖性细胞内 Ca(2+)过载。
PLoS One. 2012;7(12):e51358. doi: 10.1371/journal.pone.0051358. Epub 2012 Dec 13.
8
Calmodulin kinase II and protein kinase C mediate the effect of increased intracellular calcium to augment late sodium current in rabbit ventricular myocytes.钙调蛋白激酶 II 和蛋白激酶 C 介导细胞内钙增加的作用，增强兔心室肌细胞的晚期钠电流。
Am J Physiol Cell Physiol. 2012 Apr 15;302(8):C1141-51. doi: 10.1152/ajpcell.00374.2011. Epub 2011 Dec 21.
9
Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.磷酸肌醇3激酶（p110α）激活减少会增加心房颤动的易感性。
Am J Pathol. 2009 Sep;175(3):998-1009. doi: 10.2353/ajpath.2009.090126. Epub 2009 Aug 13.
10
Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.运动及磷酸肌醇3激酶（p110α）信号通路在扩张型和肥厚型心肌病中的保护作用
Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):612-7. doi: 10.1073/pnas.0606663104. Epub 2007 Jan 3.