Wu Po-Hsuan, Cheng Ping-Chia, Chang Chih-Ming, Lo Wu-Chia, Cheng Po-Wen
Department of Otolaryngology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Department of Communication Engineering, Asia Eastern University of Science and Technology, New Taipei City, Taiwan.
Laryngoscope. 2022 Jun;132(6):1148-1152. doi: 10.1002/lary.29818. Epub 2021 Aug 16.
OBJECTIVES/HYPOTHESIS: To evaluate the efficacy of postoperative nasal irrigation with povidone-iodine (PVP-I) solution in patients undergoing sinonasal surgery.
Single-blind, randomized controlled study.
This is a prospective, single-blind, randomized controlled study. Patients with chronic rhinosinusitis (CRS) and hypertrophic inferior turbinates who underwent endoscopic sinus surgery (ESS) and inferior turbinate reduction were enrolled in the study. Patients were evaluated using the Taiwanese version of the 22-item Sino-Nasal Outcome Test (TWSNOT-22), rhinomanometry, endoscopic examination, and bacterial cultures. One week after the operation, patients were randomly assigned to either a 0.1% PVP-I nasal irrigation group or a control (normal saline) irrigation group. We then compared the two groups' results to illustrate the effects of nasal irrigation with PVP-I solution following sinonasal surgery.
Of the 55 patients that completed the study, 27 patients were in the PVP-I group and 28 were in the control group. In both groups, the TWSNOT-22 scores, Lund-Kennedy endoscopic scores, and total nasal resistance (TNR) all revealed significant improvements at 3 months postoperatively compared with preoperative measurements (all, P < .05). However, there were no significant differences between the two groups in TWSNOT-22, endoscopic, or TNR scores 3 months after the operation (all, P > .05).
A dilute 0.1% PVP-I nasal irrigation as a postoperative care modality after sinonasal surgery did not provide additional benefit compared with normal saline irrigation.
2 Laryngoscope, 132:1148-1152, 2022.
目的/假设：评估聚维酮碘（PVP-I）溶液术后鼻腔冲洗对鼻窦手术患者的疗效。
单盲随机对照研究。
这是一项前瞻性、单盲、随机对照研究。纳入接受鼻内镜鼻窦手术（ESS）和下鼻甲切除术的慢性鼻窦炎（CRS）和下鼻甲肥大患者。使用22项中文版鼻鼻窦结局测试（TWSNOT-22）、鼻阻力测量、内镜检查和细菌培养对患者进行评估。术后1周，患者被随机分为0.1% PVP-I鼻腔冲洗组或对照组（生理盐水冲洗组）。然后比较两组结果，以说明鼻窦手术后PVP-I溶液鼻腔冲洗的效果。
在完成研究的55例患者中，PVP-I组27例，对照组28例。两组患者术后3个月的TWSNOT-22评分、Lund-Kennedy内镜评分和总鼻阻力（TNR）与术前测量相比均有显著改善（均P < 0.05）。然而，术后3个月两组在TWSNOT-22、内镜或TNR评分方面无显著差异（均P > 0.05）。
与生理盐水冲洗相比，鼻窦手术后使用稀释的0.1% PVP-I鼻腔冲洗作为术后护理方式并无额外益处。
2 喉镜，132:1148 - 1152，2022年。
