Huang Jingyu, Jiang Shixie, Wagoner Ryan, Yang Hao, Currier Glenn, Jiang Huabei
Department of Medical Engineering, University of South Florida, Tampa, Florida, USA.
Department of Psychiatry and Behavioral Neurosciences, University of South Florida, Tampa, Florida, USA.
J Xray Sci Technol. 2021;29(5):891-902. doi: 10.3233/XST-210900.
Repetitive transcranial magnetic stimulation (rTMS) of the brain is an effective clinical treatment for psychiatric disorders. Noninvasive neuroimaging during rTMS allows visualization of cortical brain activations and responses, and it is a potential tool for investigating the neurophysiological response occurring actively during stimulation. In this paper, we present a fast diffuse optical tomography (DOT) approach for three-dimensional brain mapping of hemodynamics during rTMS. Eight healthy subjects were enrolled in the study. These subjects received 10 Hz stimulation with 80%and 100%of resting motor threshold (rMT), respectively, for 4 seconds for each stimulation. Significant hemodynamic activation was observed in all cases with the strongest response when 100%rMT stimulation was applied. This work demonstrates that fast DOT has the potential to become a powerful tool for noninvasive three-dimensional imaging of the brain during rTMS.
重复经颅磁刺激（rTMS）是一种治疗精神疾病的有效临床方法。rTMS过程中的无创神经成像可使大脑皮层激活和反应可视化，是研究刺激过程中主动发生的神经生理反应的潜在工具。在本文中，我们提出了一种快速扩散光学断层扫描（DOT）方法，用于rTMS期间血流动力学的三维脑图谱绘制。八名健康受试者参与了这项研究。这些受试者分别接受10Hz的刺激，刺激强度为静息运动阈值（rMT）的80%和100%，每次刺激持续4秒。在所有情况下均观察到显著的血流动力学激活，当施加100%rMT刺激时反应最强。这项工作表明，快速DOT有潜力成为rTMS期间大脑无创三维成像的有力工具。
