Nazarova O I, Bobrov V I
Antibiot Med Biotekhnol. 1987 Nov;32(11):859-61.
Rifampicin pharmacokinetics in rats with acute affection of the liver with carbon tetrachloride did not alter. Chronic affection with carbon tetrachloride resulted in retarded elimination of the antibiotic from blood. There was observed no relationship between increased activities of transamination enzymes such as alanine aminotransferase and aspartate aminotransferase in blood serum of animals and changes in rifampicin pharmacokinetics.
利福平在四氯化碳致急性肝损伤大鼠体内的药代动力学未发生改变。四氯化碳致慢性肝损伤会导致抗生素从血液中的消除延迟。在动物血清中，谷丙转氨酶和谷草转氨酶等转氨酶活性的增加与利福平药代动力学的变化之间未观察到相关性。
