The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.
Medicine (Baltimore). 2021 Aug 13;100(32):e26912. doi: 10.1097/MD.0000000000026912.
It is essential to monitor pharmacological treatment for schizophrenic outpatients regularly in clinical practice. Especially in China, the situation of common prescribing patterns remains unclear. The objective of this study is to reveal real-world treatment prescription patterns of antipsychotics for schizophrenia patients in a representative large tertiary hospital in China.This study is a cross-sectional observational analysis of outpatients with schizophrenia in a large tertiary psychiatric hospital in Beijing, China, from May 11th to 24th, 2019. Data on subjects' socio-demographic and clinical characteristics, prescriptions of psychotropic drugs were collected from the electronic medical record (EMR) system with a standardized protocol. A multivariate analysis was performed to explore the potential association between antipsychotics treatments and subjects' characteristics.Of the 1940 patients included in this study, only 1470 (75.77%) patients were prescribed antipsychotic medications. 1228 (83.53%) patients were prescribed second-generation antipsychotics (SGAs), 202 (13.74%) patients were treated only with first-generation antipsychotics (FGAs), 40 (2.72%) were prescribed both SGAs and FGAs. The proportion of single SGAs prescriptions was significantly higher than that of single FGAs antipsychotics in each course of monotherapy group, especially among patients with the course less than 2 years (96.08%). Risperidone was most frequently prescribed antipsychotic medication during the study (29.86%, 439 out of 1470). Intermediate-acting sedative benzodiazepines were the most commonly co-prescribed psychotropic class at 23.66%. Long-acting injectable antipsychotics (LAIs) could be the prescribing trend in clinics. Disease course, self-paying cost and LAI antipsychotic use were independently associated with antipsychotics treatments.Second-generation antipsychotics showed domination in prescriptions. More concerns should be paid with concomitant psychiatric medications in clinics.
在临床实践中，定期监测精神分裂症门诊患者的药物治疗至关重要。特别是在中国，常见处方模式的情况仍不清楚。本研究旨在揭示中国一家代表性大型三级医院精神分裂症患者的抗精神病药物治疗的真实世界处方模式。
这是一项在中国北京一家大型三级精神病医院进行的精神分裂症门诊患者的横断面观察性分析。研究时间为 2019 年 5 月 11 日至 24 日。采用标准化方案从电子病历（EMR）系统中收集受试者的社会人口统计学和临床特征以及精神药物处方数据。采用多变量分析探讨抗精神病药物治疗与受试者特征之间的潜在关联。
在这项研究中，纳入了 1940 名患者，其中只有 1470 名（75.77%）患者被开具了抗精神病药物处方。1228 名（83.53%）患者被开具了第二代抗精神病药物（SGAs），202 名（13.74%）患者仅被开具了第一代抗精神病药物（FGAs），40 名（2.72%）患者被同时开具了 SGA 和 FGA。在每种单药治疗组中，单 SGA 处方的比例明显高于单 FGA 抗精神病药物，尤其是在病程小于 2 年的患者中（96.08%）。研究期间，利培酮是最常被开具的抗精神病药物（29.86%，1470 名患者中有 439 名）。中效镇静苯二氮䓬类药物是最常联合使用的精神药物类别（23.66%）。长效注射用抗精神病药物（LAIs）可能成为临床的处方趋势。病程、自费费用和使用 LAI 抗精神病药物与抗精神病药物治疗独立相关。
第二代抗精神病药物显示出主导地位。在临床中，应更加关注同时使用的精神药物。
