Kitai K, Kashiwazaki M, Adachi Y, Kunugita K, Arakawa A
Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Osaka, Japan.
Antimicrob Agents Chemother. 1987 Dec;31(12):1935-8. doi: 10.1128/AAC.31.12.1935.
The in vitro susceptibilities of eight isolates of Treponema hyodysenteriae from pigs naturally infected with swine dysentery between 1976 and 1983 were determined by an agar dilution technique. Carbadox, olaquindox, tiamulin, metronidazole, furazolidone, and monensin were the most active against these field isolates regardless of the year of recovery. The influence of inoculum size on the MICs against four reference strains of T. hyodysenteriae was studied. Various degrees of activities of ampicillin and lincomycin were found, depending on the inoculum size. The effect of successive in vitro subcultures on the susceptibility of a reference strain of T. hyodysenteriae was examined. The strain resistant to tylosin became susceptible to the drug.
采用琼脂稀释技术测定了1976年至1983年间从自然感染猪痢疾的猪中分离出的8株猪痢疾密螺旋体的体外敏感性。无论分离年份如何，卡巴氧、喹乙醇、泰妙菌素、甲硝唑、呋喃唑酮和莫能菌素对这些田间分离株的活性最强。研究了接种量对4株猪痢疾密螺旋体参考菌株最小抑菌浓度（MIC）的影响。发现氨苄西林和林可霉素的活性程度不同，这取决于接种量。检测了连续体外传代对一株猪痢疾密螺旋体参考菌株敏感性的影响。对泰乐菌素耐药的菌株变得对该药物敏感。
