吸烟与不吸烟癫痫患者体内茶碱和安替比林的代谢情况
Theophylline and antipyrine disposition in smoking and non-smoking epileptic subjects.
作者信息
Acheson D W, Uden S, Braganza J M, Brown S W, Houston J B
机构信息
University Department of Gastroenterology, Manchester Royal Infirmary.
出版信息
Br J Clin Pharmacol. 1987 Dec;24(6):812-5. doi: 10.1111/j.1365-2125.1987.tb03250.x.
Abstract
Theophylline and antipyrine disposition has been compared in smoking epileptic patients, non-smoking epileptic patients and non-smoking healthy volunteers. Although clear differences in drug clearance and half-life were evident as a result of anticonvulsant drug therapy, no effect of smoking was discernible. Thus, additive effects from induction of the hepatic microsomal monooxygenase system in man by anticonvulsant drugs and polycyclic aromatic hydrocarbons (in cigarette smoke) were not evident.
摘要
已对吸烟的癫痫患者、不吸烟的癫痫患者和不吸烟的健康志愿者体内茶碱和安替比林的代谢情况进行了比较。尽管抗惊厥药物治疗导致药物清除率和半衰期存在明显差异，但未发现吸烟有任何影响。因此，抗惊厥药物和（香烟烟雾中的）多环芳烃对人体肝微粒体单加氧酶系统的诱导作用未表现出叠加效应。
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