活性炭对甲芬那酸消除的影响。
The effect of charcoal on mefenamic acid elimination.
作者信息
Allen E M, Buss D C, Williams J, Routledge P A
机构信息
Department of Pharmacology and Therapeutics, University of Wales College of Medicine, Cardiff.
出版信息
Br J Clin Pharmacol. 1987 Dec;24(6):830-2. doi: 10.1111/j.1365-2125.1987.tb03255.x.
Mefenamic acid suppository 500 mg was administered by rectum to eight healthy adult volunteers followed by either activated charcoal 5 g orally at hourly intervals for 7 h or an equal volume of water on two separate occasions 7 days apart. Administration of charcoal did not significantly affect the pharmacokinetic variables of mefenamic acid. Thus the beneficial effects of charcoal in the treatment of mefenamic acid overdose are largely due to interference with absorption, rather than enhancement of elimination of the drug.
将500毫克甲芬那酸栓剂经直肠给予8名健康成年志愿者，随后每隔1小时口服5克活性炭，共7小时，或者在相隔7天的两个不同时间给予等量的水。给予活性炭并未显著影响甲芬那酸的药代动力学变量。因此，活性炭在治疗甲芬那酸过量中的有益作用主要是由于干扰吸收，而非增强药物的消除。
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