Galinsky R E, Levy G
J Toxicol Clin Toxicol. 1984 Jul;22(1):21-30. doi: 10.3109/00099308409035079.
Activated charcoal is an effective inhibitor of acetaminophen absorption while sodium sulfate can prevent the depletion of endogenous inorganic sulfate associated with the formation of acetaminophen sulfate. Administration of activated charcoal plus sodium sulfate soon after acetaminophen overdose may reduce acetaminophen absorption and facilitate the elimination of absorbed acetaminophen by providing sufficient sulfate ion for rapid sulfation of the drug. This investigation was designed to determine if sodium sulfate modifies the inhibitory effect of activated charcoal on acetaminophen absorption or if activated charcoal affects the absorption of sodium sulfate. Eight normal adults received, on separate occasions, 1 g acetaminophen, 1 g acetaminophen and 18 g sodium sulfate (decahydrate), 1 g acetaminophen with 10 g activated charcoal and 1 g acetaminophen, with 10 g activated charcoal and 18 g sodium sulfate, in random order. Urine was collected for 48 hours and assayed for acetaminophen and its major metabolites and for inorganic sulfate. The results confirm that activated charcoal can reduce acetaminophen absorption and show that oral administration of activated charcoal with sodium sulfate does not alter the inhibitory effect of activated charcoal on acetaminophen absorption or the bioavailability of the sulfate. A combination of activated charcoal and sodium sulfate may therefore be useful for the initial management of acetaminophen overdose.
活性炭是对乙酰氨基酚吸收的有效抑制剂，而硫酸钠可防止与对乙酰氨基酚硫酸酯形成相关的内源性无机硫酸盐耗竭。对乙酰氨基酚过量服用后不久给予活性炭加硫酸钠，可能会减少对乙酰氨基酚的吸收，并通过提供足够的硫酸根离子以促进药物快速硫酸化，从而促进已吸收的对乙酰氨基酚的消除。本研究旨在确定硫酸钠是否会改变活性炭对对乙酰氨基酚吸收的抑制作用，或者活性炭是否会影响硫酸钠的吸收。8名正常成年人在不同时间分别随机服用1克对乙酰氨基酚、1克对乙酰氨基酚和18克硫酸钠（十水合物）、1克对乙酰氨基酚加10克活性炭以及1克对乙酰氨基酚加10克活性炭和18克硫酸钠。收集尿液48小时，并检测其中对乙酰氨基酚及其主要代谢产物以及无机硫酸盐的含量。结果证实活性炭可减少对乙酰氨基酚的吸收，并表明口服活性炭与硫酸钠不会改变活性炭对对乙酰氨基酚吸收的抑制作用或硫酸盐的生物利用度。因此，活性炭和硫酸钠联合使用可能有助于对乙酰氨基酚过量的初始处理。
