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临床体征的错误认知：一名青少年患者中，脓毒症之前的胆汁淤积酷似肝炎。

The erroneous perception of a clinical sign: Cholestasis preceding sepsis mimicking hepatitis in an adolescent patient.

作者信息

Romano Fabrizio, Molinaro Marisa, Schibli Susanne, Agyeman Philipp Ka, Löllgen Ruth Mari

机构信息

Pediatric Emergency Department Department of Pediatrics, Inselspital Bern University Hospital University of Bern Bern Switzerland.

Department of Pediatrics, Inselspital Bern University Hospital University of Bern Bern Switzerland.

出版信息

Clin Case Rep. 2021 Aug 11;9(8):e04578. doi: 10.1002/ccr3.4578. eCollection 2021 Aug.

DOI:10.1002/ccr3.4578
PMID:34401159
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8357078/
Abstract

Jaundice should be considered as a first clinical sign preceding severe invasive bacterial infection or sepsis in patients of all ages including childhood and adolescence. Early laboratory investigations and MR imaging studies for osteomyelitis or myositis are paramount to avoid progression to life-threatening sepsis and significant morbidity and mortality.

摘要

黄疸应被视为包括儿童期和青春期在内的各年龄段患者发生严重侵袭性细菌感染或败血症之前的首要临床体征。对于骨髓炎或肌炎进行早期实验室检查和磁共振成像研究对于避免病情进展至危及生命的败血症以及严重的发病率和死亡率至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d078/8357078/b4afd18d1e98/CCR3-9-e04578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d078/8357078/6f2d46ef25ea/CCR3-9-e04578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d078/8357078/b4afd18d1e98/CCR3-9-e04578-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d078/8357078/6f2d46ef25ea/CCR3-9-e04578-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d078/8357078/b4afd18d1e98/CCR3-9-e04578-g002.jpg

相似文献

1
The erroneous perception of a clinical sign: Cholestasis preceding sepsis mimicking hepatitis in an adolescent patient.临床体征的错误认知：一名青少年患者中，脓毒症之前的胆汁淤积酷似肝炎。
Clin Case Rep. 2021 Aug 11;9(8):e04578. doi: 10.1002/ccr3.4578. eCollection 2021 Aug.
2
Hemoadsorption in isolated conjugated hyperbilirubinemia after extracorporeal membrane oxygenation support. Cholestasis of sepsis: A case report and review of the literature on differential causes of jaundice in ICU patient.体外膜肺氧合支持后孤立性结合胆红素血症的血液吸附。脓毒症性胆汁淤积：1例病例报告及关于ICU患者黄疸不同病因的文献综述
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[Progress in the pathogenesis of cholestasis during the early stage of sepsis].[脓毒症早期胆汁淤积发病机制的研究进展]
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[Acute hepatitis C infection with prolonged intrahepatic cholestasis and remarkable progression of fibrosis mimicking fibrosing cholestatic hepatitis].[急性丙型肝炎感染伴肝内胆汁淤积持续时间延长及纤维化显著进展，酷似纤维性胆汁淤积性肝炎]
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Jaundice and the sepsis syndrome: a neglected link.黄疸与脓毒症综合征：一个被忽视的关联。
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本文引用的文献

1
Liver - guardian, modifier and target of sepsis.肝脏——脓毒症的保护者、调节剂和靶标。
Nat Rev Gastroenterol Hepatol. 2017 Jan;14(1):55-66. doi: 10.1038/nrgastro.2016.168. Epub 2016 Dec 7.
2
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).《脓毒症及脓毒性休克第三次国际共识定义（脓毒症-3）》
JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287.
3
Liver disease in the adolescent.青少年肝病
Clin Liver Dis. 2015 Feb;19(1):171-85. doi: 10.1016/j.cld.2014.09.010. Epub 2014 Nov 21.
4
Role of MRI in the diagnosis and treatment of osteomyelitis in pediatric patients.磁共振成像在儿童骨髓炎诊断与治疗中的作用
World J Radiol. 2014 Aug 28;6(8):530-7. doi: 10.4329/wjr.v6.i8.530.
5
Sepsis-induced cholestasis.脓毒症诱导的胆汁淤积
Hepatology. 2007 Jan;45(1):230-41. doi: 10.1002/hep.21480.
6
Jaundice and the sepsis syndrome: a neglected link.黄疸与脓毒症综合征：一个被忽视的关联。
Eur J Intern Med. 2003 Jul;14(4):269-271. doi: 10.1016/s0953-6205(03)00072-4.
7
Sepsis-associated cholestasis.脓毒症相关性胆汁淤积
Gastroenterology. 1997 Jan;112(1):302-6. doi: 10.1016/s0016-5085(97)70250-6.
8
The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.用于描述器官功能障碍/衰竭的序贯器官衰竭评估（SOFA）评分。代表欧洲重症监护医学学会脓毒症相关问题工作组。
Intensive Care Med. 1996 Jul;22(7):707-10. doi: 10.1007/BF01709751.