Nakagawara Kensuke, Chubachi Shotaro, Azekawa Shuhei, Otake Shiro, Saito Ayaka, Okada Masahiko, Lee Ko, Masaki Katsunori, Koike Naoyoshi, Kamata Hirofumi, Kawada Ichiro, Suzuki Shigeaki, Ishii Makoto, Fukunaga Koichi
Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Department of Radiology, Keio University School of Medicine, Tokyo, Japan.
Respir Med Case Rep. 2021 Apr 2;33:101408. doi: 10.1016/j.rmcr.2021.101408. eCollection 2021.
Acquired immunodeficiency in thymoma (Good's syndrome) without hypogammaglobulinemia is a rare condition. Here we describe the case of a 29-year-old Japanese woman with thymoma-associated T cell immunodeficiency after radiation therapy. She was admitted to the hospital with refractory pneumonia, which resulted from as T cell immunodeficiency, as revealed through low peripheral lymphocytes and oral candidiasis triggered through radiotherapy and required long-term antimicrobial therapy. Although radiotherapy is commonly administered for thymoma, our findings suggest that physicians should consider carrying out lymphocyte counts during thymoma treatment.
胸腺瘤（古德综合征）伴无丙种球蛋白血症的获得性免疫缺陷是一种罕见病症。在此，我们描述了一名29岁日本女性在放射治疗后出现胸腺瘤相关T细胞免疫缺陷的病例。她因难治性肺炎入院，这是由T细胞免疫缺陷导致的，表现为外周淋巴细胞减少以及放疗引发的口腔念珠菌病，需要长期抗菌治疗。虽然放疗常用于胸腺瘤治疗，但我们的研究结果表明，医生在胸腺瘤治疗期间应考虑进行淋巴细胞计数。
