GATA3 阳性的泌尿系统透明细胞腺癌中的独特突变状态：病例报告
Distinct mutational status in GATA3-Positive clear cell adenocarcinoma of the urinary tract: A CASE report.
作者信息
Abdelwahab Hala, Friedman Derek, Lightle Andrea, Mian Badar, Fisher Hugh, Akgul Mahmut
机构信息
Department of Pathology and Laboratory Medicine, Albany Medical Center, Albany, NY, USA.
Department of Urology, Albany Medical Center, Albany, NY, USA.
出版信息
Urol Case Rep. 2021 Aug 1;39:101793. doi: 10.1016/j.eucr.2021.101793. eCollection 2021 Nov.
•Clear cell adenocarcinoma of the lower urinary tract is rare and poses diagnostic challenge.•GATA3, which is frequently expressed in urothelial carcinoma, can be expressed in clear cell adenocarcinoma.•ARID1A, PBRM1, ERBB4, and SMARCA4 mutations were identified in the current CASE.•Molecular studies may aid in the diagnosis, and optimal treatment decision-making process.
•下尿路透明细胞腺癌罕见，诊断颇具挑战。
•GATA3在尿路上皮癌中常表达，也可在透明细胞腺癌中表达。
•本病例中鉴定出ARID1A、PBRM1、ERBB4和SMARCA4突变。
•分子研究可能有助于诊断及优化治疗决策过程。
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