瑞芬太尼诱导内化后，膜联蛋白A2将μ-阿片受体捕获在再循环内体中。
Annexin A2 traps mu-opioid receptors in recycling endosomes upon remifentanil-induced internalization.
作者信息
Ho Idy H T, Ng Lhotse H L, Cheng Xiaojie, Gin Tony, Chan Chee Sam, Sun Wuping, Xiao Lizu, Zhang Lin, Chan Matthew T V, Wu William K K, Liu Xiaodong
机构信息
Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Special Administrative Region, China.
Peter Hung Pain Research Institute, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China.
出版信息
Neurobiol Pain. 2021 Aug 2;10:100071. doi: 10.1016/j.ynpai.2021.100071. eCollection 2021 Aug-Dec.
•ANXA2 is a novel MOR1-interacting protein regulating MOR1 sub-cellular localization.•ANXA2 retains MOR1 in late recycling endosomes after remifentanil exposure.
•膜联蛋白A2是一种调节MOR1亚细胞定位的新型与MOR1相互作用蛋白。
•瑞芬太尼暴露后，膜联蛋白A2将MOR1保留在晚期再循环内体中。
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