Puel J L, Uziel A
INSERM--U.254, Laboratoire de Neurobiologie de l'Audition, Montpellier, France.
Brain Res. 1987 Dec 15;465(1-2):179-88. doi: 10.1016/0165-3806(87)90239-2.
The present study was undertaken in order to study the rate of maturation of the cochlear action potential sensitivity, latency, and tuning curves for various stimulus frequencies and to correlate the development of latency and frequency selectivity with threshold development. This study showed a two-stage model of maturation in which thresholds and latencies declined rapidly and linearly during the first stage, and slowly and exponentially during the last stage. These results suggest that latencies and thresholds are influenced by similar maturational processes. The correlative study of frequency selectivity and thresholds showed a linear relationship during the period of rapid maturation, and conversely, a dissociation between the development of tuning and threshold during the late period of slow acquisition of adult sensitivity. This dissociation was particularly marked at 8 kHz where Q10 values continued to increase even when thresholds were adultlike. These results were discussed in relation to anatomical and functional data available from the rat cochlea.
本研究旨在探讨不同刺激频率下耳蜗动作电位的敏感性、潜伏期和调谐曲线的成熟速率，并将潜伏期和频率选择性的发展与阈值发展相关联。本研究显示了一个两阶段成熟模型，其中阈值和潜伏期在第一阶段迅速且呈线性下降，而在最后阶段缓慢且呈指数下降。这些结果表明潜伏期和阈值受相似的成熟过程影响。频率选择性与阈值的相关性研究显示，在快速成熟阶段呈线性关系，相反，在缓慢获得成人敏感性的后期，调谐发展与阈值之间出现分离。这种分离在8kHz处尤为明显，即使阈值已达到成人水平，Q10值仍继续增加。结合从大鼠耳蜗获得的解剖学和功能数据对这些结果进行了讨论。
