脊髓损伤后减轻继发性损伤的治疗靶点和基于纳米材料的治疗方法。
Therapeutic targets and nanomaterial-based therapies for mitigation of secondary injury after spinal cord injury.
机构信息
Department of Bioengineering, Drug Design, Development & Delivery (4D) Laboratory, Clemson University, Clemson, SC 29634, USA.
Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.
出版信息
Nanomedicine (Lond). 2021 Sep;16(22):2013-2028. doi: 10.2217/nnm-2021-0113. Epub 2021 Aug 17.
Abstract
Spinal cord injury (SCI) and the resulting neurological trauma commonly result in complete or incomplete neurological dysfunction and there are few effective treatments for primary SCI. However, the following secondary SCI, including the changes of microvasculature, inflammatory response and oxidative stress around the injury site, may provide promising therapeutic targets. The advances of nanomaterials hold promise for delivering therapeutics to alleviate secondary SCI and promote functional recovery. In this review, we highlight recent achievements of nanomaterial-based therapy, specifically targeting blood-spinal cord barrier disruption, mitigation of the inflammatory response and lightening of oxidative stress after spinal cord injury.
摘要
脊髓损伤 (SCI) 及由此导致的神经创伤通常会导致完全或不完全的神经功能障碍，且针对原发性 SCI 几乎没有有效的治疗方法。然而，以下继发性 SCI，包括损伤部位周围的微血管变化、炎症反应和氧化应激，可能提供有希望的治疗靶点。纳米材料的进展为提供治疗药物以减轻继发性 SCI 和促进功能恢复提供了希望。在这篇综述中，我们强调了基于纳米材料的治疗的最新进展，特别是针对血脊髓屏障破坏、减轻炎症反应和减轻脊髓损伤后的氧化应激。
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Mol Neurobiol. 2020 Jun;57(6):2671-2689. doi: 10.1007/s12035-020-01914-5. Epub 2020 Apr 16.
3
MiRNA-125a-5p attenuates blood-spinal cord barrier permeability under hypoxia in vitro.
Biotechnol Lett. 2020 Jan;42(1):25-34. doi: 10.1007/s10529-019-02753-8. Epub 2019 Nov 6.
4
Inhibition of microRNA-711 limits angiopoietin-1 and Akt changes, tissue damage, and motor dysfunction after contusive spinal cord injury in mice.
Cell Death Dis. 2019 Nov 4;10(11):839. doi: 10.1038/s41419-019-2079-y.
5
Incidence of acute spinal cord injury and associated complications of methylprednisolone therapy: a national population-based study in South Korea.
Spinal Cord. 2020 Feb;58(2):232-237. doi: 10.1038/s41393-019-0357-2. Epub 2019 Sep 16.
6
Brilliant Blue G Inhibits Inflammasome Activation and Reduces Disruption of Blood-Spinal Cord Barrier Induced by Spinal Cord Injury in Rats.
Med Sci Monit. 2019 Aug 24;25:6359-6366. doi: 10.12659/MSM.915865.
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