Kishi Y, Hashimoto Y, Sakamoto Y, Inui S
Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima, Japan.
Cancer. 1987 Nov 1;60(9):2331-6. doi: 10.1002/1097-0142(19871101)60:9<2331::aid-cncr2820600936>3.0.co;2-o.
The minimum thickness of cervical fibromuscular stroma remaining uninvolved with invasive cervical carcinoma was examined in relation to pelvic node metastases and 5-year cancer death rate, using specimens from Stage IB, IIA, and IIB patients who underwent radical hysterectomy and pelvic lymphadenectomy. The nodal metastasis and 5-year cancer death rates were 7% and 8%, respectively, in patients with the uninvolved fibromuscular stroma thickness above 3 mm, and 37% and 26%, respectively, in patients with the thickness below 3 mm. The thickness of cancer-unaffected cervical fibromuscular stroma seemed to be closely related to and to be a more useful parameter of the biological behavior of invasive cervical carcinoma than the depth of the cancer invasion. A threshold value of the minimum thickness of the tissue as a barrier against extrauterine spread of cervical cancer could not be identified in this study.
利用接受根治性子宫切除术和盆腔淋巴结清扫术的IB期、IIA期和IIB期患者的标本，研究了未受浸润性宫颈癌累及的宫颈纤维肌性基质的最小厚度与盆腔淋巴结转移及5年癌症死亡率之间的关系。未受浸润的纤维肌性基质厚度大于3mm的患者，其淋巴结转移率和5年癌症死亡率分别为7%和8%；而厚度小于3mm的患者，上述比率分别为37%和26%。未受癌症影响的宫颈纤维肌性基质厚度似乎与浸润性宫颈癌的生物学行为密切相关，并且相较于癌症浸润深度，它是一个更有用的参数。在本研究中，未能确定作为阻止宫颈癌宫外扩散屏障的组织最小厚度的阈值。
