A.N.Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, 119991, Vavilova St. 28, Moscow, Russian Federation.
University of Southern California, 1002 Childs Way, Los Angeles, CA, 90089-3502, USA.
Chemistry. 2021 Nov 5;27(62):15327-15360. doi: 10.1002/chem.202101768. Epub 2021 Sep 30.
The efficient chemo-, regio- and stereoselective formation of saturated carbon-carbon fragment is the critical challenge of organic synthesis; therefore, developing new methods for formation of these bonds is paramount. The rising interest for reductive aldol-type reactions is conditioned by its versatile applications, allowing the efficient formation of carbon-carbon bonds. The review aims to highlight the advantages and disadvantage of reductive aldol-type reactions to total synthesis of pharmaceutical substances in order to summarize knowledge and encourage further investigation of the field.
高效的碳-碳键的形成是有机合成的关键挑战，因此，开发新的方法来形成这些键至关重要。还原羟醛型反应的兴趣日益增加，这是由于其应用广泛，能够有效地形成碳-碳键。本综述旨在突出还原羟醛型反应在药物全合成中的优点和缺点，以总结知识并鼓励进一步研究该领域。
