虚拟现实作为癌症患者化疗支持治疗焦虑和疲劳的系统评价和meta 分析及未来研究方向。
Virtual reality as a chemotherapy support in treatment of anxiety and fatigue in patients with cancer: A systematic review and meta-analysis and future research directions.
机构信息
Opole University of Technology, Faculty of Physical Education and Physiotherapy, Opole, Poland.
Descartes' Error Student Research Association, Faculty of Physical Education and Physiotherapy, Opole University of Technology, Opole, Poland.
出版信息
Complement Ther Med. 2021 Sep;61:102767. doi: 10.1016/j.ctim.2021.102767. Epub 2021 Aug 14.
OBJECTIVE
The aim of this systematic review was to analyse the effectiveness of virtual reality intervention as an aid for treatment-related anxiety and fatigue in cancer patients undergoing chemotherapy. The term chemotherapy was assumed without distinction regarding type.
METHODS
The inclusion criteria were (1) randomised controlled trials or crossover studies, (2) adult cancer patients undergoing chemotherapy, (3) treatment with VR scenarios providing distraction during chemotherapy, and (4) with pain, anxiety, fatigue, fear, or symptom distress as the measured outcomes. Articles in English, Polish, and Italian were sought. For the methodological quality assessment of risk of bias, likewise statistical analysis and meta-analysis the RevMan version 5.4 software and the Cochrane Risk of Bias Tool were used. Two authors independently analysed the following databases for relevant research articles: PubMed, Scopus, Cochrane Library, Web of Science, and Embase.
RESULTS
From a total of 2543 records, 6 studies met the inclusion criteria for qualitative analysis. At the end of the process, 3 studies remained for quantitative analysis. The systematic review includes three randomised, controlled studies and three crossover studies with an overall sample size of 453 patients. The analysis of the primary outcomes chosen for each study revealed no significant differences between the control and experimental conditions. Moreover, an important factor influencing the results of the review and meta-analysis was the poor quality of the publications available on the topic of distraction during chemotherapy.
CONCLUSION
Due to the low research standards, the results do not provide an unambiguous answer to the research question. The most important limitations result from the small number of trials, the generally small sample sizes, and the differences in study design.
目的
本系统评价旨在分析虚拟现实干预作为一种辅助治疗癌症患者化疗相关焦虑和疲劳的方法的有效性。化疗一词没有区分其类型。
方法
纳入标准为：（1）随机对照试验或交叉研究；（2）接受化疗的成年癌症患者；（3）接受 VR 场景治疗以分散化疗注意力；（4）以疼痛、焦虑、疲劳、恐惧或症状困扰为测量结果。搜索的文章语言为英语、波兰语和意大利语。使用 RevMan 版本 5.4 软件和 Cochrane 偏倚风险工具评估风险偏倚的方法学质量评估、统计分析和荟萃分析。两位作者独立分析了以下数据库中的相关研究文章：PubMed、Scopus、Cochrane 图书馆、Web of Science 和 Embase。
结果
从总共 2543 条记录中，有 6 项研究符合定性分析的纳入标准。在整个过程结束时，有 3 项研究仍需进行定量分析。系统评价包括 3 项随机对照研究和 3 项交叉研究，总样本量为 453 例患者。对每个研究选择的主要结局进行分析，结果显示对照组和实验组之间没有显著差异。此外，影响综述和荟萃分析结果的一个重要因素是有关化疗期间分散注意力的可用出版物质量较差。
结论
由于研究标准较低，结果并不能对研究问题给出明确的答案。最重要的限制因素来自于试验数量少、总体样本量小以及研究设计的差异。
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