Zhang Y X, Zhang S N
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
Zhonghua Shao Shang Za Zhi. 2021 Aug 20;37(8):705-710. doi: 10.3760/cma.j.cn501120-20210701-00232.
Pathological scars cause both local physical discomforts and mental disorders for patients. With the development of research, botulinum toxin type A (BTX-A) has been gradually used in the clinical treatment of scars. This article summarizes three potential mechanisms of BTX-A, including early tension reduction, inhibition of connective tissue hyperplasia, and alleviation of skin inflammation, as well as the clinical application of BTX-A in treating different types of scars. However, at present there is no uniform standard for the time, method, and proportioning of BTX-A injection for scar treatment, and there is also a lack of long-term follow-up results. Further researches are needed in future to clarify the mechanism of BTX-A in inhibiting scars, establish a uniform protocol of BTX-A injection, and provide a more effective treatment plan for scars.
病理性瘢痕给患者带来局部身体不适和精神障碍。随着研究的发展，A型肉毒毒素（BTX-A）已逐渐应用于瘢痕的临床治疗。本文总结了BTX-A的三种潜在作用机制，包括早期减轻张力、抑制结缔组织增生和减轻皮肤炎症，以及BTX-A在治疗不同类型瘢痕中的临床应用。然而，目前BTX-A用于瘢痕治疗的注射时间、方法和配比尚无统一标准，且缺乏长期随访结果。未来需要进一步研究以阐明BTX-A抑制瘢痕的机制，建立统一的BTX-A注射方案，并为瘢痕提供更有效的治疗方案。
