The First Affiliate Hospital of Jinan University, Jinan University, Guangzhou, 510630, China.
International Joint Laboratory for Embryonic Development & Prenatal Medicine, Division of Histology and Embryology, Medical College, Jinan University, Guangzhou, 510632, China.
Reprod Biol Endocrinol. 2021 Aug 17;19(1):126. doi: 10.1186/s12958-021-00807-z.
In late December 2019, the COVID-19 pandemic caused a great threat to people's lives worldwide. As a special category of the population, pregnant women are vulnerable during emergencies. This study was designed to explore whether or not the COVID-19 pandemic has influenced maternal and infant outcomes. We collected maternal characteristics, laboratory results, condition in the third trimester, maternal outcome, fetal or neonatal outcomes, and characteristics of amniotic fluid, umbilical cord and placenta from pregnant women and fetals or newborns in the first affiliated hospital of Jinan university from 24 January to 31 March 2020 (peak period), chose the same types of data at the hospital during the same period in 2019 and 1 January-23 January 2020 (prior to the outbreak of COVID-19 in 2020) as a control. Our study focused on uncomplicated singleton pregnancies among women not infected by COVID-19. The results demonstrated that there was not an increase in adverse outcomes of pregnant women and newborns during the COVID-19 pandemic; This might be associated with the updated design of major epidemic prevention and control systems in Guangzhou, and the extension of pregnant women's rest time during the third trimester of pregnancy. Nevertheless, the survey showed an increased incidence rate of 25-hydroxyvitamin D and zinc deficiency in newborns during the epidemic, implying that pregnant women should participate in appropriate physical exercise, increase their exposure to outdoor sunlight and improve nutrition intake to ensure healthy newborns during the quarantine period. Our study has provided some guidance for maternal management during the COVID-19 pandemic.
2019 年 12 月底，COVID-19 大流行对全球人民的生命健康造成了巨大威胁。作为一个特殊的人群，孕妇在紧急情况下处于脆弱状态。本研究旨在探讨 COVID-19 大流行是否对母婴结局产生影响。我们收集了孕妇的一般特征、实验室结果、妊娠晚期情况、母婴结局、胎儿或新生儿结局以及羊水、脐带和胎盘的特征，这些数据来自 2020 年 1 月 24 日至 3 月 31 日（高峰期）期间在暨南大学第一附属医院的孕妇及其胎儿或新生儿，选择了同期在 2019 年和 2020 年 1 月 1 日-23 日（2020 年 COVID-19 爆发之前）的相同类型的数据作为对照。我们的研究重点是未感染 COVID-19 的孕妇的简单单胎妊娠。结果表明，COVID-19 大流行期间孕妇和新生儿不良结局并未增加；这可能与广州重大疫情防控体系的更新设计以及延长孕妇妊娠晚期休息时间有关。然而，该调查显示，在疫情期间，新生儿 25-羟维生素 D 和锌缺乏的发生率增加，这表明孕妇应在隔离期间适当参加体育锻炼，增加户外阳光照射，改善营养摄入，以确保新生儿健康。本研究为 COVID-19 大流行期间的母婴管理提供了一些指导。
