Yu Hang, Ma Cui, Zhu Da-Ling
Branch Campus of Daqing, Harbin Medical University, Daqing 163311, China.
College of Pharmacy, Harbin Medical University, Harbin 158100, China.
Sheng Li Xue Bao. 2021 Aug 25;73(4):646-656.
Pulmonary arterial hypertension (PAH) is a rare disease with a complex aetiology characterized by elevated pulmonary artery resistance, which leads to progressive right ventricular failure and ultimately death. The aberrant metabolism of arachidonic acid in the pulmonary vasculature plays a central role in the pathogenesis of PAH. The levels of 15-lipoxygenase (15-LO) and 15-hydroxyeicosatetraenoic acid (15-HETE) are elevated in the pulmonary arterial endothelial cells (PAECs), pulmonary smooth muscle cells (PASMCs) and fibroblasts of PAH patients. Under hypoxia condition, 15-LO/15-HETE induces pulmonary artery contraction, promotes the proliferation of PAECs and PASMCs, inhibits apoptosis of PASMCs, promotes fibrosis of pulmonary vessels, and then leads to the occurrence of PAH. Here, we review the research progress on the relationship between 15-LO/15-HETE and hypoxic PAH, in order to clarify the significance of 15-LO/15-HETE in hypoxic PAH.
肺动脉高压（PAH）是一种病因复杂的罕见疾病，其特征是肺动脉阻力升高，这会导致进行性右心室衰竭并最终导致死亡。肺血管中花生四烯酸的异常代谢在PAH的发病机制中起核心作用。在PAH患者的肺动脉内皮细胞（PAECs）、肺平滑肌细胞（PASMCs）和成纤维细胞中，15-脂氧合酶（15-LO）和15-羟基二十碳四烯酸（15-HETE）的水平升高。在缺氧条件下，15-LO/15-HETE诱导肺动脉收缩，促进PAECs和PASMCs的增殖，抑制PASMCs的凋亡，促进肺血管纤维化，进而导致PAH的发生。在此，我们综述15-LO/15-HETE与缺氧性PAH之间关系的研究进展，以阐明15-LO/15-HETE在缺氧性PAH中的意义。
