Jin Ju Hyun, Kim Yeejeong, Yoo Jongha, Kim Eui Hyeok, Yoon Shin Won
Department of Pediatrics, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Department of Pathology, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
Infect Chemother. 2022 Jun;54(2):372-377. doi: 10.3947/ic.2021.0027. Epub 2021 Jul 28.
It is unclear how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) affects pregnant women and their fetuses or newborns. We report two infants born to mothers with coronavirus disease 2019 (COVID-19) in Korea. The first case was a healthy female baby born at 39 weeks' gestation from a mother diagnosed with COVID-19. The second case was a female baby born at 38 weeks' gestation. The newborn in the second case had symptoms of respiratory distress immediately after birth, and nasal continuous positive airway pressure support was applied for 8 hours. Real-time polymerase chain reaction test results for SARS-CoV-2 using amniotic fluid, neonatal nasopharyngeal and oropharyngeal swabs, blood, urine, stool, and rectal swab were all negative in the 1st and 2nd days of life in both cases. Placental pathology showed acute necrotizing deciduitis and intervillous fibrin deposition with acute intervillositis. Although clinical evidence of vertical transmission was not found in our cases, with the possibility of placental inflammation, close monitoring of SARS-CoV-2 positive mothers and their newborn is required.
目前尚不清楚严重急性呼吸综合征冠状病毒2（SARS-CoV-2）如何影响孕妇及其胎儿或新生儿。我们报告了韩国两名母亲患有2019冠状病毒病（COVID-19）的婴儿。第一例是一名健康女婴，在孕39周时出生，其母亲被诊断为COVID-19。第二例是一名在孕38周时出生的女婴。第二例中的新生儿出生后立即出现呼吸窘迫症状，并接受了8小时的鼻持续气道正压通气支持。在这两例中，出生后第1天和第2天，使用羊水、新生儿鼻咽和口咽拭子、血液、尿液、粪便及直肠拭子进行的SARS-CoV-2实时聚合酶链反应检测结果均为阴性。胎盘病理显示急性坏死性蜕膜炎、绒毛间纤维蛋白沉积伴急性绒毛间炎。尽管在我们的病例中未发现垂直传播的临床证据，但鉴于存在胎盘炎症的可能性，需要对SARS-CoV-2阳性母亲及其新生儿进行密切监测。
