甲状腺碘化系统中NADPH氧化位点和过氧化物酶-H2O2的区室化要求。
Requirement of a compartmentalization for NADPH oxidizing site and peroxidase-H2O2 in the thyroid iodinating system.
作者信息
Ait Hammou N, Virion A, Deme D, Pommier J
机构信息
INSERM-U. 96, Unité de Recherche sur la Glande Thyroide et la Régulation Hormonale, Bicêtre, France.
出版信息
Horm Metab Res. 1987 Dec;19(12):606-8. doi: 10.1055/s-2007-1011891.
PMID:3440565
Abstract
In this study, it is shown that NADPH iodination occurs in a thyroid peroxidase-H2O2 system in presence of thyroglobulin, the normal iodination substrate. Previous data suggested that thyroid H2O2 generation is a NADPH-dependent system. Present results support the concept of a compartmentalization of the sites of NADPH oxidation and peroxidasic iodination.
摘要
本研究表明，在正常碘化底物甲状腺球蛋白存在的情况下，甲状腺过氧化物酶-H2O2体系中会发生NADPH碘化反应。先前的数据表明，甲状腺H2O2的生成是一个依赖NADPH的体系。目前的结果支持NADPH氧化位点和过氧化物酶碘化位点存在区室化的概念。
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