与HC毒素序列相关的环四肽。构象与阳离子结合。
Cyclic tetrapeptides with sequences related to HC toxin. Conformations and cation binding.
作者信息
Heitz F, Kaddari F, Heitz A, Raniriseheno H, Lazaro R
机构信息
Laboratory of Polyphasic System Physicochemistry--UA 330, Montpellier, France.
出版信息
Int J Pept Protein Res. 1987 Dec;30(6):801-7. doi: 10.1111/j.1399-3011.1987.tb03389.x.
Abstract
Peptides with sequences related to HC toxin (cyclo(LAla-DAla-L-Aoe-DPro] can adopt a conformation locked by three gamma turns. A "structure--spectroscopy characteristics" relationship is proposed. These peptides can complex Mg++ cations and the binding is accompanied by a transconformation of the peptide backbone. The relevance with the biological activity of the toxin is discussed.
摘要
具有与HC毒素相关序列（环（L-丙氨酸-D-丙氨酸-L-草氨酸-D-脯氨酸））的肽可以采用由三个γ-转角锁定的构象。提出了一种“结构-光谱特征”关系。这些肽可以与Mg++阳离子形成复合物，并且结合伴随着肽主链的反式构象变化。讨论了其与毒素生物活性的相关性。
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