Hidiroglou M
Animal Research Centre, Research Branch Agriculture Canada, Ottawa, Ontario.
Int J Vitam Nutr Res. 1987;57(4):381-4.
Five groups, each of 5 sheep of 40-45 kg body weight were used. One group acted as control (killed at 0 time, no vitamin E dose) while the other four groups were given a single oral dose of d-alpha-tocopherol acetate (100 mg/kg body weight) and killed 24, 48, 72 and 240 h after dosing. Samples of adrenal, adipose, heart, liver, kidney, lung, muscle, pancreas and spleen were taken from all 25 sheep and were analyzed for their vitamin E content. In the control sheep the tocopherol concentration in some tissues such as pancreas and adrenal were substantially higher than in the other tissues. Muscle and adipose tissue contained the lowest tocopherol concentrations among the various tissues. Tissues responded differently to the vitamin E dosing. Liver was characterized by a rapid accumulation of alpha-tocopherol at 24 h followed by a progressive loss. In the adrenal and lung the peak occurred 48 h after vitamin E loading. The variable pattern in tocopherol concentrations in the various sheep tissues following vitamin E dosing was considered a reflection of their different metabolic activities.
选用五组，每组5只体重40 - 45千克的绵羊。一组作为对照组（在0时刻处死，未给予维生素E剂量），而其他四组给予单次口服剂量的d-α-生育酚醋酸酯（100毫克/千克体重），并在给药后24、48、72和240小时处死。从所有25只绵羊身上采集肾上腺、脂肪、心脏、肝脏、肾脏、肺、肌肉、胰腺和脾脏的样本，并分析其维生素E含量。在对照绵羊中，某些组织如胰腺和肾上腺中的生育酚浓度明显高于其他组织。肌肉和脂肪组织在各种组织中生育酚浓度最低。不同组织对维生素E给药的反应不同。肝脏的特点是在24小时时α-生育酚迅速积累，随后逐渐减少。在肾上腺和肺中，维生素E负荷后48小时出现峰值。维生素E给药后不同绵羊组织中生育酚浓度的变化模式被认为反映了它们不同的代谢活性。
