Hawkins T D, Szaz K F
Department of Diagnostic Radiology, Addenbrooke's Hospital, Cambridge, England.
Invest Radiol. 1987 Dec;22(12):969-72. doi: 10.1097/00004424-198712000-00010.
Previous studies have shown that a silicone rubber balloon filled with a hyperosmolar solution of contrast medium expands and may rupture because the wall acts as a semipermeable membrane. The deflation of latex rubber balloons in vivo has been attributed to the same cause. The authors investigated the behavior of latex rubber balloons filled with metrizamide solutions ranging from hyperosmolar to hypo-osmolar relative to plasma. When balloons were immersed in plasma, tritiated water passed bidirectionally through the wall at a rate unrelated to the concentration or volume of the contrast medium in the balloon. There was no exchange of sodium ions across the wall, and the osmolality of the metrizamide did not change over a period of up to six weeks. The authors conclude that deflation of a latex rubber balloon during the first few hours or days is not due to osmosis.
先前的研究表明，填充有高渗造影剂溶液的硅橡胶球囊会膨胀并可能破裂，因为球囊壁起到了半透膜的作用。体内乳胶气球的放气也被归因于同一原因。作者研究了填充有相对于血浆从高渗到低渗的甲泛葡胺溶液的乳胶气球的行为。当气球浸入血浆中时，氚标记的水以与球囊内造影剂的浓度或体积无关的速率双向穿过球囊壁。没有钠离子穿过球囊壁的交换，并且甲泛葡胺的渗透压在长达六周的时间内没有变化。作者得出结论，乳胶气球在最初几个小时或几天内的放气不是由于渗透作用。
