母亲百日咳疫苗接种对保护新生儿的有效性：一项配对病例对照研究。

Effectiveness of maternal pertussis vaccination in protecting newborn: A matched case-control study.

作者信息

Godoy Pere, García-Cenoz Manuel, Rius Cristina, Muñoz-Almagro Carmen, Carmona Gloria, Alsedà Miquel, Jané Mireia, Vidal Maria-José, Rodríguez Raquel, Álvarez Josep, Camps Neus, Minguell Sofia, Carol Mónica, Sala Maria-Rosa, Castilla Jesús, Domínguez Àngela

机构信息

Agència de Salut Pública de Catalunya. Barcelona, Spain; Ciber de Epidemiología y Salud Pública. CIBERESP. Madrid, Spain; Institut de Recerca Biomèdica de Lleida. IRBLleida. Lleida, Spain.

Ciber de Epidemiología y Salud Pública. CIBERESP. Madrid, Spain; Instituto de Salud Pública de Navarra - idiSNA, Pamplona, Spain.

出版信息

J Infect. 2021 Nov;83(5):554-558. doi: 10.1016/j.jinf.2021.08.022. Epub 2021 Aug 15.

DOI:10.1016/j.jinf.2021.08.022

PMID:34407422

Abstract

INTRODUCTION

The objective was to estimate the effectiveness of maternal pertussis vaccination in protecting infants aged < 2 months.

METHODS

We performed a case-control study. Laboratory-confirmed cases aged <8 weeks at disease onset were identified and 2-4 matched-controls born within ± 15 days of the case were included. Information was obtained from healthcare providers and maternal interviews. Odds ratios (OR) were calculated using multivariable conditional logistic regression. Vaccine effectiveness (VE) was estimated as (1 - OR) × 100%.

RESULTS

47 cases and 124 controls were studied. The mean age (in days) (39.8 ± 12.7 vs. 40.8 ± 13.2), weeks of gestation (38.8 vs. 39.1, p = 0.43) and mean birth weight (3.309 vs. 3.253 kg, p = 0.55) were comparable between cases and controls. Mothers of cases were less frequently vaccinated in the third trimester (59.6% vs. 83.9%, p <0.001). The VE of maternal vaccination in pregnancy was 88.0% (95%CI 53.8% -96.5%), and was slightly higher in those vaccinated before the 32nd week of gestation (88.5% vs 87.8%).

CONCLUSION

Pertussis vaccination in pregnancy is very effective in reducing pertussis in children aged < 2 months. Vaccination before and after the 32nd week of pregnancy are equally effective in reducing the risk of pertussis.

摘要

引言

目的是评估孕妇百日咳疫苗接种对保护2个月以下婴儿的有效性。

方法

我们进行了一项病例对照研究。确定发病时年龄小于8周且实验室确诊的病例，并纳入在病例发病±15天内出生的2 - 4名匹配对照。信息来自医疗服务提供者和对母亲的访谈。使用多变量条件逻辑回归计算比值比（OR）。疫苗有效性（VE）估计为(1 - OR)×100%。

结果

研究了47例病例和124名对照。病例组和对照组的平均年龄（天数）（39.8±12.7对40.8±13.2）、孕周（38.8对39.1，p = 0.43）和平均出生体重（3.309对3.253 kg，p = 0.55）具有可比性。病例组母亲在孕晚期接种疫苗的频率较低（59.6%对83.9%，p<0.001）。孕期母亲接种疫苗的VE为88.0%（95%CI 53.8% - 96.5%），在妊娠32周前接种疫苗的母亲中略高（88.5%对87.8%）。