Japan Small Animal Cancer Center, 1-10-4 Higashi-Tokorozawa, Tokorozawa-shi, Saitama 359-0023, Japan.
Nishiyama Animal Clinic, 4-11-14 Morooka-cho, Ome-shi, Tokyo 198-0031, Japan.
J Vet Med Sci. 2021 Oct 5;83(10):1554-1558. doi: 10.1292/jvms.21-0254. Epub 2021 Aug 17.
Primary hepatic neuroendocrine tumors (PHNETs) are rare in dogs, and limited information exists about the treatment of these tumors. A 12-year-old castrated male French bulldog was presented to our clinic with gastrointestinal signs. Diagnostic tests revealed increased hepatic enzyme levels, a mass in the hepatic quadrate lobe, multiple intrahepatic nodules, and enlarged hepatic hilar lymph nodes. The liver mass was diagnosed cytologically as a malignant epithelial tumor suspected to be of neuroendocrine origin. The dog was treated with single-agent toceranib phosphate (TOC) and survived 25.1 months after the initial presentation. On necropsy, a liver mass was found and was subsequently diagnosed as a PHNET on histopathology. To the best of our knowledge, this is the first report of long-term survival in a dog with PHNET treated with TOC.
原发性肝神经内分泌肿瘤（PHNET）在犬中较为罕见，针对这些肿瘤的治疗方法的相关信息有限。一只 12 岁已去势的雄性法国斗牛犬因胃肠道症状就诊于我院。诊断性检查显示肝酶水平升高，肝方叶有肿块，多个肝内结节和肝门淋巴结肿大。肝肿块的细胞学诊断为恶性上皮肿瘤，疑似神经内分泌来源。该犬接受了单药托西莫单抗磷酸（TOC）治疗，自首次就诊后存活了 25.1 个月。尸检时发现肝脏有肿块，随后在组织病理学上诊断为 PHNET。据我们所知，这是首例使用 TOC 治疗 PHNET 并长期存活的犬病例报告。
