Chandrashekar Laxmisha, Rajappa Medha, Rajendiran Kalai Selvi, Munisamy Malathi
Department of Dermatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Postepy Dermatol Alergol. 2021 Feb;38(2):156-158. doi: 10.5114/ada.2021.104291. Epub 2021 Mar 10.
Recent studies on pathomechanisms of vitiligo have focused on the abnormality of keratinocytes that affect the melanocytes. Aquaporin-3 (AQP3) was implicated as a mechanism for keratinocyte apoptosis owing to the relationship between the PI3K/AKT pathway and the E-cadherin-catenin complex.
Based on this evidence, we undertook a cross-sectional study to assess the skin and blood AQP-3 levels in patients with non-segmental vitiligo in comparison to controls and to correlate these levels with malondialdehyde (MDA) levels and total antioxidant status (TAS) in the skin and blood of patients with non-segmental vitiligo and also with their disease activity.
Thirty-six patients with non-segmental vitiligo and 36 controls were included in this study. AQP3, TAS and MDA levels were assayed both in skin as well as in circulation.
We observed that skin and plasma aquaporin and TAS were lowered and MDA levels were increased in patients with non-segmental vitiligo as compared to controls. There was a significant negative correlation of skin and plasma aquaporin levels with disease activity. We also observed the local and systemic AQP3 deficiency to correlate with the local and systemic oxidative stress in vitiligo.
Our results demonstrate a systemic and local AQP3 deficiency in vitiligo correlating with the disease severity and oxidative stress which might have therapeutic implications.
近期关于白癜风发病机制的研究聚焦于影响黑素细胞的角质形成细胞异常。水通道蛋白3（AQP3）因PI3K/AKT信号通路与E-钙黏蛋白-连环蛋白复合物之间的关系，被认为是角质形成细胞凋亡的一种机制。
基于上述证据，我们开展了一项横断面研究，以评估非节段型白癜风患者皮肤和血液中AQP-3水平，并与对照组进行比较，同时将这些水平与非节段型白癜风患者皮肤和血液中的丙二醛（MDA）水平及总抗氧化状态（TAS）相关联，还与疾病活动度相关联。
本研究纳入了36例非节段型白癜风患者和36例对照。对皮肤及循环系统中的AQP3、TAS和MDA水平进行检测。
我们观察到，与对照组相比，非节段型白癜风患者皮肤和血浆中的水通道蛋白及TAS水平降低，MDA水平升高。皮肤和血浆水通道蛋白水平与疾病活动度呈显著负相关。我们还观察到白癜风局部和全身的AQP3缺乏与局部和全身氧化应激相关。
我们的结果表明，白癜风存在全身和局部AQP3缺乏，与疾病严重程度和氧化应激相关，这可能具有治疗意义。
