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肾移植受者的播散性组织胞浆菌病:外周血涂片是关键。

Disseminated histoplasmosis in a renal transplantation recipient: Peripheral blood smear was the key.

作者信息

Samannodi Mohammed, Minshawi Faisal, Hasbun Rodrigo

机构信息

Department of Medicine, College of Medicine, Umm AlQura University, Makkah, Saudi Arabia.

Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia.

出版信息

Med Mycol Case Rep. 2021 Aug 8;33:30-31. doi: 10.1016/j.mmcr.2021.08.001. eCollection 2021 Sep.

DOI:10.1016/j.mmcr.2021.08.001
PMID:34408965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8361280/
Abstract

Disseminated histoplasmosis is common in immunocompromised patients such as patients with AIDS, hematologic malignancies, transplant recipients, and those on prolonged corticosteroid use. We report the case of a 53-year-old man with a history of end-stage renal disease due to uncontrolled hypertension who underwent renal transplantation in 2013. He presented to the hospital with a 5-day history of dyspnea, and blood tests showed pancytopenia. The diagnosis of disseminated histoplasmosis was made rapidly by peripheral blood smear. We encourage clinicians to check peripheral blood smear if disseminated histoplasmosis is suspected.

摘要

播散性组织胞浆菌病在免疫功能低下的患者中很常见,如艾滋病患者、血液系统恶性肿瘤患者、移植受者以及长期使用皮质类固醇的患者。我们报告一例53岁男性病例,该患者因高血压控制不佳导致终末期肾病,于2013年接受了肾移植。他因呼吸困难5天入院,血液检查显示全血细胞减少。通过外周血涂片迅速确诊为播散性组织胞浆菌病。我们鼓励临床医生在怀疑播散性组织胞浆菌病时检查外周血涂片。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d116/8361280/f9501b3c2a3c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d116/8361280/f9501b3c2a3c/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d116/8361280/f9501b3c2a3c/gr1.jpg

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本文引用的文献

1
Laboratory Diagnostics for Histoplasmosis.组织胞浆菌病的实验室诊断
J Clin Microbiol. 2017 Jun;55(6):1612-1620. doi: 10.1128/JCM.02430-16. Epub 2017 Mar 8.
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Peripheral blood candidiasis.外周血念珠菌病
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Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients.艾滋病毒感染患者中杜波伊斯荚膜组织胞浆菌感染的文献综述及病例史。
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Candida albicans blastoconidia in peripheral blood smears from non-neutropenic surgical patients.非中性粒细胞减少的外科手术患者外周血涂片上的白色念珠菌芽生孢子。
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Disseminated histoplasmosis in renal allograft recipients.肾移植受者的播散性组织胞浆菌病
Clin Transplant. 1996 Apr;10(2):160-5.
9
Disseminated histoplasmosis in a renal transplant patient: a cause of renal failure several years following transplantation.肾移植患者的播散性组织胞浆菌病:移植数年之后肾衰竭的一个病因。
Am J Kidney Dis. 1991 Jun;17(6):719-21. doi: 10.1016/s0272-6386(12)80359-3.