Yang Deng-Ho, Chin Chun-Shih, Chao Wen-Cheng, Lin Ching-Heng, Chen Yun-Wen, Chen Yi-Hsing, Chen Hsin-Hua
Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan.
Department of Medical Laboratory Science and Biotechnology, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Front Med (Lausanne). 2021 Aug 2;8:713262. doi: 10.3389/fmed.2021.713262. eCollection 2021.
This study aimed to assess the associations of the risk of asthma diagnosed in children aged 6 years or younger and having maternal immune-mediated inflammatory diseases (IMIDs), including systemic lupus erythematosus (SLE), systemic sclerosis (SSc), inflammatory myositis, rheumatoid arthritis (RA), Sjögren's syndrome (SS), ankylosing spondylitis (AS), and autoimmune thyroiditis. A total of 628,878 singleton newborns documented in 2006-2009 and followed up for at least 6 years were identified. Overall, 153,085 (24.3%) children developed asthma at the age of ≤ 6 years. Two groups of maternal ages, i.e., <35 and ≥35 years, were evaluated. The associations of the risk of asthma occurring in children who were 6 years old or younger and had maternal IMIDs were examined. The risk of asthma increased in children whose mothers had SLE [odds ratio (OR), 1.13; 95% confidence intervals (CI), 1.00-1.27; = 0.04), RA (OR, 1.21; 95% CI, 1.07-1.38; = 0.003), inflammatory myositis (OR, 1.41; 95% CI, 1.12-1.74; = 0.003), asthma (OR, 1.58; 95% CI, 1.52-1.63), allergic rhinitis (OR, 1.30; 95% CI, 1.28-1.32), or atopic dermatitis (OR, 1.07; 95% CI, 1.02-1.12). Conversely, this increased risk was not observed in children whose mothers had AS (OR, 1.02; 95% CI, 0.87-1.20), SS (OR, 0.96; 95% CI, 0.86-1.07), SSc (OR, 1.28; 95% CI, 0.77-2.14), or autoimmune thyroiditis (OR, 1.01; 95% CI, 0.95-1.07). Other risk factors of childhood asthma included high urbanization level, preterm birth, and low birth weight. The risk of childhood asthma at 6 years of age increased in children whose mothers suffered from SLE, RA, inflammatory myositis, asthma, allergic rhinitis, and atopic dermatitis.
本研究旨在评估6岁及以下儿童患哮喘的风险与母亲患免疫介导的炎症性疾病（IMIDs）之间的关联，这些疾病包括系统性红斑狼疮（SLE）、系统性硬化症（SSc）、炎性肌病、类风湿关节炎（RA）、干燥综合征（SS）、强直性脊柱炎（AS）和自身免疫性甲状腺炎。共确定了2006年至2009年记录在案且至少随访6年的628,878名单胎新生儿。总体而言，153,085名（24.3%）儿童在6岁及以下时患哮喘。评估了两组母亲年龄，即<35岁和≥35岁。研究了6岁及以下儿童且母亲患有IMIDs时患哮喘风险的关联。母亲患有SLE[比值比（OR），1.13；95%置信区间（CI），1.00 - 1.27；P = 0.04]、RA（OR，1.21；95% CI，1.07 - 1.38；P = 0.003）、炎性肌病（OR，1.41；95% CI，1.12 - 1.74；P = 0.003）、哮喘（OR，1.58；95% CI，1.52 - 1.63）、过敏性鼻炎（OR，1.30；95% CI，1.28 - 1.32）或特应性皮炎（OR，1.07；95% CI，1.02 - 1.12）时，儿童患哮喘的风险增加。相反，母亲患有AS（OR，1.02；95% CI，0.87 - 1.20）、SS（OR，0.96；95% CI，0.86 - 1.07）、SSc（OR，1.28；95% CI，0.77 - 2.14）或自身免疫性甲状腺炎（OR，1.01；95% CI，0.95 - 1.07）的儿童未观察到这种风险增加。儿童哮喘的其他风险因素包括城市化水平高、早产和低出生体重。母亲患有SLE、RA、炎性肌病、哮喘、过敏性鼻炎和特应性皮炎的儿童在6岁时患儿童哮喘的风险增加。
