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鼠骨髓间充质基质/干细胞和人胎盘提取物对多柔比星致大鼠睾丸毒性的治疗作用。

Therapeutic Effect of Murine Bone Marrow-Derived Mesenchymal Stromal/Stem Cells and Human Placental Extract on Testicular Toxicity Resulting from Doxorubicin in Rats.

机构信息

Biology Department, College of Science, Jouf University, P.O. Box 2014, Sakaka, Saudi Arabia.

Zoology Department Faculty of Science, Al-Azhar University, Cairo, Egypt.

出版信息

Biomed Res Int. 2021 Aug 6;2021:9979670. doi: 10.1155/2021/9979670. eCollection 2021.

DOI:10.1155/2021/9979670
PMID:34409109
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8367585/
Abstract

Oncotherapeutics like doxorubicin can affect male gonads; as a result, it leads to infertility. This work was conducted to demonstrate the toxic effects of doxorubicin on testes of male albino rats. Fifty male albino rats aged 5-7 weeks were used in this study. The animals were randomly separated into 5 sets (each set containing ten rats). Group I received saline (i.p.) for 4 weeks. Group II was given doxorubicin (DOX), 5 mg/kg BW (i.p.) once/week for 4 weeks. Groups III and IV were treated in the same way as the DOX group, left for one week without medication, and then injected with mesenchymal stromal cells (MSCs) or human placental extract (HPE) therapy in a single dose of 5 × 10 in 200 ml PRP/week or 40 l placental extract for 4 weeks via the caudal vein. Group V rats were treated in the same way as the DOX group also, left for one week without medication, and then injected with MSC+HPE. A significant decrease in serum testosterone, FSH, and LH levels was observed in rats treated with DOX compared to the control group. A significant elevation was recorded in rats treated with DOX+MSC or DOX+HPE when compared with the DOX group only. Rats that were given MSC+HPE after DOX intoxication showed a significant increase in hormone levels when compared to rats treated with either MSC or HPE. Light and electron microscopic examinations revealed that DOX intoxication initiated degenerative and necrotic changes in seminiferous tubules associated with partial or complete cessation of spermatogenesis. These effects were reversed by the effect of MSC or HPE. Coadministration of MSC and HPE even showed further improvement. Finally, we can say that doxorubicin has a deleterious impact on rat testes; however, therapeutic effects can be induced through MSC and/or HPE administration.

摘要

多柔比星等肿瘤治疗药物会影响男性性腺，从而导致不育。本研究旨在探讨多柔比星对雄性大白鼠睾丸的毒性作用。将 50 只 5-7 周龄雄性大白鼠用于本研究。将动物随机分为 5 组（每组 10 只）。第 I 组腹腔注射生理盐水（i.p.）4 周；第 II 组腹腔注射多柔比星（DOX），5mg/kg BW，每周 1 次，共 4 周；第 III 组和第 IV 组处理方式与 DOX 组相同，停药 1 周，然后单次静脉注射间充质基质细胞（MSC）或人胎盘提取物（HPE）治疗，剂量为 5×10 在 200ml PRP/周或 40μl 胎盘提取物，共 4 周；第 V 组处理方式与 DOX 组相同，停药 1 周，然后静脉注射 MSC+HPE。与对照组相比，多柔比星处理组大鼠血清睾酮、FSH 和 LH 水平显著降低。与仅接受 DOX 处理的大鼠相比，接受 DOX+MSC 或 DOX+HPE 处理的大鼠的这些激素水平显著升高。与单独接受 MSC 或 HPE 治疗的大鼠相比，DOX 中毒后接受 MSC+HPE 治疗的大鼠的激素水平显著升高。光镜和电镜检查显示，多柔比星中毒导致曲细精管发生退行性和坏死性改变，与精子发生部分或完全停止有关。MSC 或 HPE 的作用可逆转这些影响。MSC 和 HPE 联合给药甚至显示出进一步的改善。总之，多柔比星对大鼠睾丸有有害影响，但通过 MSC 和/或 HPE 给药可以诱导治疗效果。

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